Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease
2015
Autori
Joksić, JelenaSopić, Miron
Spasojević-Kalimanovska, Vesna
Kalimanovska-Oštrić, Dimitra
Anđelković, Kristina
Jelić-Ivanović, Zorana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P =... 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P lt 0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.
Ključne reči:
resistin, human / gene expression / coronary artery disease / acute coronary syndromeIzvor:
Biochemia Medica, 2015, 25, 2, 242-251Izdavač:
- Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
Finansiranje / projekti:
- Interaktivna uloga dislipidemije, oksidativnog stresa i inflamacije u aterosklerozi i drugim bolestima: genetički i biohemijski markeri (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.11613/BM.2015.025
ISSN: 1330-0962
PubMed: 26110037
WoS: 000356588100012
Scopus: 2-s2.0-84930444382
Institucija/grupa
PharmacyTY - JOUR AU - Joksić, Jelena AU - Sopić, Miron AU - Spasojević-Kalimanovska, Vesna AU - Kalimanovska-Oštrić, Dimitra AU - Anđelković, Kristina AU - Jelić-Ivanović, Zorana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2465 AB - Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P lt 0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine. PB - Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb T2 - Biochemia Medica T1 - Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease VL - 25 IS - 2 SP - 242 EP - 251 DO - 10.11613/BM.2015.025 ER -
@article{ author = "Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Anđelković, Kristina and Jelić-Ivanović, Zorana", year = "2015", abstract = "Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P lt 0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.", publisher = "Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb", journal = "Biochemia Medica", title = "Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease", volume = "25", number = "2", pages = "242-251", doi = "10.11613/BM.2015.025" }
Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Anđelković, K.,& Jelić-Ivanović, Z.. (2015). Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. in Biochemia Medica Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb., 25(2), 242-251. https://doi.org/10.11613/BM.2015.025
Joksić J, Sopić M, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Anđelković K, Jelić-Ivanović Z. Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. in Biochemia Medica. 2015;25(2):242-251. doi:10.11613/BM.2015.025 .
Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Anđelković, Kristina, Jelić-Ivanović, Zorana, "Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease" in Biochemia Medica, 25, no. 2 (2015):242-251, https://doi.org/10.11613/BM.2015.025 . .