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dc.creatorJoksić, Jelena
dc.creatorSopić, Miron
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKalimanovska-Oštrić, Dimitra
dc.creatorAnđelković, Kristina
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:48:40Z
dc.date.available2019-09-02T11:48:40Z
dc.date.issued2015
dc.identifier.issn1330-0962
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2465
dc.description.abstractIntroduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P lt 0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.en
dc.publisherCroatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceBiochemia Medica
dc.subjectresistin, humanen
dc.subjectgene expressionen
dc.subjectcoronary artery diseaseen
dc.subjectacute coronary syndromeen
dc.titleCirculating resistin protein and mRNA concentrations and clinical severity of coronary artery diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСопић, Мирон; Aнђелковић, Кристина; Јелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Јоксић, Јелена; Калимановска-Оштрић, Димитра;
dc.citation.volume25
dc.citation.issue2
dc.citation.spage242
dc.citation.epage251
dc.citation.other25(2): 242-251
dc.citation.rankM21
dc.identifier.wos000356588100012
dc.identifier.doi10.11613/BM.2015.025
dc.identifier.pmid26110037
dc.identifier.scopus2-s2.0-84930444382
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1143/2463.pdf
dc.identifier.rcubconv_3331
dc.type.versionpublishedVersion


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