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Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)

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2015
2469.pdf (1.900Mb)
Authors
Savić, Ivan
Nikolić, Vesna D.
Savić-Gajić, Ivana
Nikolić, Ljubiša
Ibrić, Svetlana
Gajić, Dragoljub G.
Article (Published version)
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Abstract
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.
Keywords:
amygdalin / plum seeds / extraction / central composite design / multilayer perceptron / isolation / structural characterization
Source:
Frontiers in Plant Science, 2015, 6
Publisher:
  • Frontiers Media Sa, Lausanne
Projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.3389/fpls.2015.00276

ISSN: 1664-462X

PubMed: 25972881

WoS: 000356894600001

Scopus: 2-s2.0-84934877490
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2471
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  • Radovi istraživača / Researchers’ publications
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Pharmacy

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