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dc.creatorSavić, Ivan
dc.creatorNikolić, Vesna D.
dc.creatorSavić-Gajić, Ivana
dc.creatorNikolić, Ljubiša
dc.creatorIbrić, Svetlana
dc.creatorGajić, Dragoljub G.
dc.date.accessioned2019-09-02T11:48:49Z
dc.date.available2019-09-02T11:48:49Z
dc.date.issued2015
dc.identifier.issn1664-462X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2471
dc.description.abstractThe process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer was used for describing the extraction process. MLP model was more superior compared with CCD model due to better prediction ability. According to MLP model, the suggested optimal conditions are: time of 120 min, 100% (v/v) ethanol, solid-to liquid ratio of 1:25 (m/v) and temperature of 34.4 degrees C. The predicted value of amygdalin content in the dried extract (25.42 g per 100 g) at these conditions was experimentally confirmed (25.30 g per 100 g of dried extract). Amygdalin (>90%) was isolated from the complex extraction mixture and structurally characterized by FT-IR, UV, and MS methods.en
dc.publisherFrontiers Media Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS//
dc.rightsopenAccess
dc.sourceFrontiers in Plant Science
dc.subjectamygdalinen
dc.subjectplum seedsen
dc.subjectextractionen
dc.subjectcentral composite designen
dc.subjectmultilayer perceptronen
dc.subjectisolationen
dc.subjectstructural characterizationen
dc.titleOptimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)en
dc.typearticle
dc.rights.licenseBY
dcterms.abstractСавић-Гајић, Ивана; Савић, Иван М.; Николић, Весна Д.; Николић, Љубиша; Гајић, Драгољуб Г.; Ибрић, Светлана;
dc.citation.volume6
dc.citation.other6: -
dc.citation.rankaM21
dc.identifier.wos000356894600001
dc.identifier.doi10.3389/fpls.2015.00276
dc.identifier.pmid25972881
dc.identifier.scopus2-s2.0-84934877490
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1149/2469.pdf
dc.identifier.rcubconv_3335
dc.type.versionpublishedVersion


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