FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće

Thumbnail
2015
2477.pdf (473.5Kb)
Authors
Vidojević, Aleksandra
Živković, Aleksandra
Santrač, Anja
Divović, Branka
Savić, Miroslav
Article (Published version)
Metadata
Show full item record
Abstract
Introduction: Animal models enable the investigation of association between maternal inflammation during pregnancy and different neuropsychiatric disorders in offspring, which has been reported in epidemiological studies. Aim: Investigation of inflammation existence in female rats exposed to LPS during pregnancy and its influence on spatial memory impairment in offspring in Morris water maze. Material and methods: Pregnant Wistar females were exposed to LPS or saline (SAL) at gestational day 15 and 16 and their blood was taken for TNF-α concentration determination. Rats of both sexes (male - M, female - F) went through five-day memory acquisition and one-day memory retrieval test during two periods (35 - 39 postnatal day (P35-39) and P40; likewise P55-59 and P60). We analyzed memory acquisition (latency and path efficiency to platform finding and total distance travelled) and memory retrieval parameters (number of entries and path efficiency to first entry to the target zone). Results:... We found higher TNF-α concentration present in LPS-treated dams. There were no significant differences for any of the parameters analyzed for P40 animals and P60 females. M/LPS/P60 rats had a significantly decreased path efficiency to platform finding, increased total distance travelled and a trend of increased latency to platform finding, compared to M/SAL/P60 in the memory acquisition test, and a significantly decreased path efficiency to first entry to the target zone in the memory retrieval test. Conclusion: Lipopolysaccharide (LPS) - induced maternal inflammation during pregnancy leads to spatial memory impairment in male rat offspring in early adulthood, a finding that can be a basis for animal modeling of neurodevelopmental disorders.

Uvod: Animalni modeli pružaju mogućnost ispitivanja veze između zapaljenja kod majki tokom trudnoće i različitih neuropsihijatrijskih poremećaja potomstva, pokazane u epidemiološkim studijama. Cilj rada: U ovom radu je ispitivano postojanje zapaljenja kod ženki pacova izloženih LPS-u tokom trudnoće i njegov uticaj na oštećenje prostorne memorije potomstva u Morisovom vodenom lavirintu. Materijal i metode: Gravidne ženke soja Wistar bile su izložene LPS-u ili fiziološkom rastvoru (SAL) 15. i 16. dana gestacije i uzimana im je krv radi određivanja koncentracije TNF-α. Mladunci oba pola (mužjaci - M, ženke - F) podvrgnuti su petodnevnom testu sticanja i jednodnevnom testu pozivanja memorije u dva postnatalna perioda (35 - 39. postnatalnog dana života (P35- 39) i P40, odnosno P55-59 i P60). Analizirani su parametri sticanja (latencija i efikasnost putanje do pronalaska platforme i ukupan pređeni put) i pozivanja prostorne memorije (broj ulazaka i efikasnost putanje do prvog ulaska u ciljnu... zonu). Rezultati: Utvrđene su povišene koncentracije TNF-α kod majki tretiranih LPS-om. Kod P40 životinja nije bilo značajnih razlika u praćenim bihejvioralnim parametrima, kao ni kod P60 ženki. Pokazano je da su pacovi M/LPS/P60 imali statistički značajno manju efikasnost putanje do pronalaska platforme, veći ukupni pređeni put i trend povećanja latencije do pronalaska platforme u odnosu na M/SAL/P60 u testu sticanja memorije, kao i značajno manju efikasnost putanje do prvog ulaska u ciljnu zonu u testu pozivanja memorije. Zaključak: Lipopolisaharidom (LPS) izazvano zapaljenje kod ženki pacova tokom trudnoće utiče na oštećenje prostorne memorije kod potomstva muškog pola u ranom odraslom dobu, što bi moglo poslužiti za razvijanje animalnog modela neurorazvojnih oboljenja.

Keywords:
lipopolysaccharide / spatial memory / TNF-α / neurodevelopmental impairment / inflammation in gravidity / lipopolisaharid / prostorna memorija / TNF-α / neurorazvojno oštećenje / zapaljenje u graviditetu
Source:
Medicinski podmladak, 2015, 66, 2, 37-43
Publisher:
  • Univerzitet u Beogradu - Medicinski fakultet, Beograd

DOI: 10.5937/medpodm1502037V

ISSN: 0369-1527

[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2479
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Vidojević, Aleksandra
AU  - Živković, Aleksandra
AU  - Santrač, Anja
AU  - Divović, Branka
AU  - Savić, Miroslav
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2479
AB  - Introduction: Animal models enable the investigation of association between maternal inflammation during pregnancy and different neuropsychiatric disorders in offspring, which has been reported in epidemiological studies. Aim: Investigation of inflammation existence in female rats exposed to LPS during pregnancy and its influence on spatial memory impairment in offspring in Morris water maze. Material and methods: Pregnant Wistar females were exposed to LPS or saline (SAL) at gestational day 15 and 16 and their blood was taken for TNF-α concentration determination. Rats of both sexes (male - M, female - F) went through five-day memory acquisition and one-day memory retrieval test during two periods (35 - 39 postnatal day (P35-39) and P40; likewise P55-59 and P60). We analyzed memory acquisition (latency and path efficiency to platform finding and total distance travelled) and memory retrieval parameters (number of entries and path efficiency to first entry to the target zone). Results: We found higher TNF-α concentration present in LPS-treated dams. There were no significant differences for any of the parameters analyzed for P40 animals and P60 females. M/LPS/P60 rats had a significantly decreased path efficiency to platform finding, increased total distance travelled and a trend of increased latency to platform finding, compared to M/SAL/P60 in the memory acquisition test, and a significantly decreased path efficiency to first entry to the target zone in the memory retrieval test. Conclusion: Lipopolysaccharide (LPS) - induced maternal inflammation during pregnancy leads to spatial memory impairment in male rat offspring in early adulthood, a finding that can be a basis for animal modeling of neurodevelopmental disorders.
AB  - Uvod: Animalni modeli pružaju mogućnost ispitivanja veze između zapaljenja kod majki tokom trudnoće i različitih neuropsihijatrijskih poremećaja potomstva, pokazane u epidemiološkim studijama. Cilj rada: U ovom radu je ispitivano postojanje zapaljenja kod ženki pacova izloženih LPS-u tokom trudnoće i njegov uticaj na oštećenje prostorne memorije potomstva u Morisovom vodenom lavirintu. Materijal i metode: Gravidne ženke soja Wistar bile su izložene LPS-u ili fiziološkom rastvoru (SAL) 15. i 16. dana gestacije i uzimana im je krv radi određivanja koncentracije TNF-α. Mladunci oba pola (mužjaci - M, ženke - F) podvrgnuti su petodnevnom testu sticanja i jednodnevnom testu pozivanja memorije u dva postnatalna perioda (35 - 39. postnatalnog dana života (P35- 39) i P40, odnosno P55-59 i P60). Analizirani su parametri sticanja (latencija i efikasnost putanje do pronalaska platforme i ukupan pređeni put) i pozivanja prostorne memorije (broj ulazaka i efikasnost putanje do prvog ulaska u ciljnu zonu). Rezultati: Utvrđene su povišene koncentracije TNF-α kod majki tretiranih LPS-om. Kod P40 životinja nije bilo značajnih razlika u praćenim bihejvioralnim parametrima, kao ni kod P60 ženki. Pokazano je da su pacovi M/LPS/P60 imali statistički značajno manju efikasnost putanje do pronalaska platforme, veći ukupni pređeni put i trend povećanja latencije do pronalaska platforme u odnosu na M/SAL/P60 u testu sticanja memorije, kao i značajno manju efikasnost putanje do prvog ulaska u ciljnu zonu u testu pozivanja memorije. Zaključak: Lipopolisaharidom (LPS) izazvano zapaljenje kod ženki pacova tokom trudnoće utiče na oštećenje prostorne memorije kod potomstva muškog pola u ranom odraslom dobu, što bi moglo poslužiti za razvijanje animalnog modela neurorazvojnih oboljenja.
PB  - Univerzitet u Beogradu - Medicinski fakultet, Beograd
T2  - Medicinski podmladak
T1  - Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće
VL  - 66
IS  - 2
SP  - 37
EP  - 43
DO  - 10.5937/medpodm1502037V
ER  - 
@article{
author = "Vidojević, Aleksandra and Živković, Aleksandra and Santrač, Anja and Divović, Branka and Savić, Miroslav",
year = "2015",
abstract = "Introduction: Animal models enable the investigation of association between maternal inflammation during pregnancy and different neuropsychiatric disorders in offspring, which has been reported in epidemiological studies. Aim: Investigation of inflammation existence in female rats exposed to LPS during pregnancy and its influence on spatial memory impairment in offspring in Morris water maze. Material and methods: Pregnant Wistar females were exposed to LPS or saline (SAL) at gestational day 15 and 16 and their blood was taken for TNF-α concentration determination. Rats of both sexes (male - M, female - F) went through five-day memory acquisition and one-day memory retrieval test during two periods (35 - 39 postnatal day (P35-39) and P40; likewise P55-59 and P60). We analyzed memory acquisition (latency and path efficiency to platform finding and total distance travelled) and memory retrieval parameters (number of entries and path efficiency to first entry to the target zone). Results: We found higher TNF-α concentration present in LPS-treated dams. There were no significant differences for any of the parameters analyzed for P40 animals and P60 females. M/LPS/P60 rats had a significantly decreased path efficiency to platform finding, increased total distance travelled and a trend of increased latency to platform finding, compared to M/SAL/P60 in the memory acquisition test, and a significantly decreased path efficiency to first entry to the target zone in the memory retrieval test. Conclusion: Lipopolysaccharide (LPS) - induced maternal inflammation during pregnancy leads to spatial memory impairment in male rat offspring in early adulthood, a finding that can be a basis for animal modeling of neurodevelopmental disorders., Uvod: Animalni modeli pružaju mogućnost ispitivanja veze između zapaljenja kod majki tokom trudnoće i različitih neuropsihijatrijskih poremećaja potomstva, pokazane u epidemiološkim studijama. Cilj rada: U ovom radu je ispitivano postojanje zapaljenja kod ženki pacova izloženih LPS-u tokom trudnoće i njegov uticaj na oštećenje prostorne memorije potomstva u Morisovom vodenom lavirintu. Materijal i metode: Gravidne ženke soja Wistar bile su izložene LPS-u ili fiziološkom rastvoru (SAL) 15. i 16. dana gestacije i uzimana im je krv radi određivanja koncentracije TNF-α. Mladunci oba pola (mužjaci - M, ženke - F) podvrgnuti su petodnevnom testu sticanja i jednodnevnom testu pozivanja memorije u dva postnatalna perioda (35 - 39. postnatalnog dana života (P35- 39) i P40, odnosno P55-59 i P60). Analizirani su parametri sticanja (latencija i efikasnost putanje do pronalaska platforme i ukupan pređeni put) i pozivanja prostorne memorije (broj ulazaka i efikasnost putanje do prvog ulaska u ciljnu zonu). Rezultati: Utvrđene su povišene koncentracije TNF-α kod majki tretiranih LPS-om. Kod P40 životinja nije bilo značajnih razlika u praćenim bihejvioralnim parametrima, kao ni kod P60 ženki. Pokazano je da su pacovi M/LPS/P60 imali statistički značajno manju efikasnost putanje do pronalaska platforme, veći ukupni pređeni put i trend povećanja latencije do pronalaska platforme u odnosu na M/SAL/P60 u testu sticanja memorije, kao i značajno manju efikasnost putanje do prvog ulaska u ciljnu zonu u testu pozivanja memorije. Zaključak: Lipopolisaharidom (LPS) izazvano zapaljenje kod ženki pacova tokom trudnoće utiče na oštećenje prostorne memorije kod potomstva muškog pola u ranom odraslom dobu, što bi moglo poslužiti za razvijanje animalnog modela neurorazvojnih oboljenja.",
publisher = "Univerzitet u Beogradu - Medicinski fakultet, Beograd",
journal = "Medicinski podmladak",
title = "Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće",
volume = "66",
number = "2",
pages = "37-43",
doi = "10.5937/medpodm1502037V"
}
Vidojević, A., Živković, A., Santrač, A., Divović, B.,& Savić, M.. (2015). Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće. in Medicinski podmladak
Univerzitet u Beogradu - Medicinski fakultet, Beograd., 66(2), 37-43.
https://doi.org/10.5937/medpodm1502037V
Vidojević A, Živković A, Santrač A, Divović B, Savić M. Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće. in Medicinski podmladak. 2015;66(2):37-43.
doi:10.5937/medpodm1502037V .
Vidojević, Aleksandra, Živković, Aleksandra, Santrač, Anja, Divović, Branka, Savić, Miroslav, "Sticanje i pozivanje prostorne memorije kod potomstva ženki pacova izloženih lipopolisaharidom izazvanom zapaljenju tokom trudnoće" in Medicinski podmladak, 66, no. 2 (2015):37-43,
https://doi.org/10.5937/medpodm1502037V . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB