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Determination of fluocortolone pivalate and fluocortolone hexanoate in suppositories using reverse-phase HPLC
dc.creator | Čudina, Olivera | |
dc.creator | Brborić, Jasmina | |
dc.creator | Vujić, Zorica | |
dc.creator | Radulović, D | |
dc.creator | Vladimirov, S | |
dc.date.accessioned | 2019-09-02T10:52:10Z | |
dc.date.available | 2019-09-02T10:52:10Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 0014-827X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/247 | |
dc.description.abstract | Fluocortolone and its esters are synthetic corticosteroids used topically in the treatment of various skin disorders. A method that can be successfully used for the separation and determination of fluocortolone pivalate and fluocortolone hexanoate in suppositories was developed. This method is based on reverse-phase HPLC on Supelcosil LC-18 (25 cm x 4.6 mm, 5 mu m), using methanol-acetonitrile-water-glacial acetic acid (17: 46:37:0.4 v/v/v/v) as mobile phase at a flow rate of 3.0 ml/min. Detection was carried out using a UV detector at 238 nm. The method developed was validated, and calibration curves were established dependent on peak area. The validated ranges for fluocortolone pivalate and fluocortolone hexanoate are 15-305 mu g/ml (r = 0.9995) and 15-315 mu g/ml (r = 0.9996), respectively. The limits of detection and the limits of quantification for both esters were also determined. | en |
dc.publisher | Elsevier Science Sa, Lausanne | |
dc.rights | restrictedAccess | |
dc.source | Farmaco | |
dc.title | Determination of fluocortolone pivalate and fluocortolone hexanoate in suppositories using reverse-phase HPLC | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Брборић, Јасмина; Владимиров, С; Радуловић, Д; Чудина, Оливера; Вујић, Зорица; | |
dc.citation.volume | 55 | |
dc.citation.issue | 2 | |
dc.citation.spage | 125 | |
dc.citation.epage | 127 | |
dc.citation.other | 55(2): 125-127 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000086306600008 | |
dc.identifier.doi | 10.1016/S0014-827X(00)00003-3 | |
dc.identifier.pmid | 10782383 | |
dc.identifier.scopus | 2-s2.0-0034104845 | |
dc.type.version | publishedVersion |