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dc.creatorČudina, Olivera
dc.creatorBrborić, Jasmina
dc.creatorVujić, Zorica
dc.creatorRadulović, D
dc.creatorVladimirov, S
dc.date.accessioned2019-09-02T10:52:10Z
dc.date.available2019-09-02T10:52:10Z
dc.date.issued2000
dc.identifier.issn0014-827X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/247
dc.description.abstractFluocortolone and its esters are synthetic corticosteroids used topically in the treatment of various skin disorders. A method that can be successfully used for the separation and determination of fluocortolone pivalate and fluocortolone hexanoate in suppositories was developed. This method is based on reverse-phase HPLC on Supelcosil LC-18 (25 cm x 4.6 mm, 5 mu m), using methanol-acetonitrile-water-glacial acetic acid (17: 46:37:0.4 v/v/v/v) as mobile phase at a flow rate of 3.0 ml/min. Detection was carried out using a UV detector at 238 nm. The method developed was validated, and calibration curves were established dependent on peak area. The validated ranges for fluocortolone pivalate and fluocortolone hexanoate are 15-305 mu g/ml (r = 0.9995) and 15-315 mu g/ml (r = 0.9996), respectively. The limits of detection and the limits of quantification for both esters were also determined.en
dc.publisherElsevier Science Sa, Lausanne
dc.rightsrestrictedAccess
dc.sourceFarmaco
dc.titleDetermination of fluocortolone pivalate and fluocortolone hexanoate in suppositories using reverse-phase HPLCen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБрборић, Јасмина; Владимиров, С; Радуловић, Д; Чудина, Оливера; Вујић, Зорица;
dc.citation.volume55
dc.citation.issue2
dc.citation.spage125
dc.citation.epage127
dc.citation.other55(2): 125-127
dc.citation.rankM23
dc.identifier.wos000086306600008
dc.identifier.doi10.1016/S0014-827X(00)00003-3
dc.identifier.pmid10782383
dc.identifier.scopus2-s2.0-0034104845
dc.type.versionpublishedVersion


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