Chitosan-based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers
Abstract
Over the past few decades, chitosans have gained great attention in the field of biomedicine. Unique cationic nature, biocompatibility, biodegradability, origin from renewable sources, and diversity make these biopolymers good candidates for micro- and nanoencapsulation of cells, genes, proteins, and structurally different drugs. Under suitable conditions, these polycations can interact with various polyanions, creating assemblies known as polyelectrolyte complexes (PECs) with physicochemical properties that significantly differ from those of the individual polymers. The reversible nature of interaction between comprising polymers and stimuli-responsive nature, particularly the pH sensitivity, makes PECs suitable for drug delivery applications. This chapter summarizes basic principles of polyelectrolyte complexation and discusses the importance of experimental conditions (e.g., pH value and ionic strength of the reaction medium, concentration, and ratio of individual polymers) and the ...influence of relevant functional properties of chitosans (e.g., molecular weight, degree of deacetylation, and viscosity) on this process. The chapter discusses in detail the overall effect of chitosan-based PECs on morphology, encapsulation efficiency, stability, and drug release properties of anionic-based particulate drug carriers. Finally, a brief overview of various physicochemical and biopharmaceutical techniques that can be applied for characterization of these complexes and related particulate drug carriers is presented.
Keywords:
Chitosan / Drug delivery / Particulate drug carriers / Polyelectrolyte complexSource:
Advanced Theranostics Materials, 2015, 235-270Publisher:
- Wiley
Funding / projects:
- Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
- Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-172041)
Collections
Institution/Community
PharmacyTY - CHAP AU - Čalija, Bojan AU - Cekić, Nebojša AU - Milić, Jela PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2480 AB - Over the past few decades, chitosans have gained great attention in the field of biomedicine. Unique cationic nature, biocompatibility, biodegradability, origin from renewable sources, and diversity make these biopolymers good candidates for micro- and nanoencapsulation of cells, genes, proteins, and structurally different drugs. Under suitable conditions, these polycations can interact with various polyanions, creating assemblies known as polyelectrolyte complexes (PECs) with physicochemical properties that significantly differ from those of the individual polymers. The reversible nature of interaction between comprising polymers and stimuli-responsive nature, particularly the pH sensitivity, makes PECs suitable for drug delivery applications. This chapter summarizes basic principles of polyelectrolyte complexation and discusses the importance of experimental conditions (e.g., pH value and ionic strength of the reaction medium, concentration, and ratio of individual polymers) and the influence of relevant functional properties of chitosans (e.g., molecular weight, degree of deacetylation, and viscosity) on this process. The chapter discusses in detail the overall effect of chitosan-based PECs on morphology, encapsulation efficiency, stability, and drug release properties of anionic-based particulate drug carriers. Finally, a brief overview of various physicochemical and biopharmaceutical techniques that can be applied for characterization of these complexes and related particulate drug carriers is presented. PB - Wiley T2 - Advanced Theranostics Materials T1 - Chitosan-based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers SP - 235 EP - 270 DO - 10.1002/9781118998922.ch9 ER -
@inbook{ author = "Čalija, Bojan and Cekić, Nebojša and Milić, Jela", year = "2015", abstract = "Over the past few decades, chitosans have gained great attention in the field of biomedicine. Unique cationic nature, biocompatibility, biodegradability, origin from renewable sources, and diversity make these biopolymers good candidates for micro- and nanoencapsulation of cells, genes, proteins, and structurally different drugs. Under suitable conditions, these polycations can interact with various polyanions, creating assemblies known as polyelectrolyte complexes (PECs) with physicochemical properties that significantly differ from those of the individual polymers. The reversible nature of interaction between comprising polymers and stimuli-responsive nature, particularly the pH sensitivity, makes PECs suitable for drug delivery applications. This chapter summarizes basic principles of polyelectrolyte complexation and discusses the importance of experimental conditions (e.g., pH value and ionic strength of the reaction medium, concentration, and ratio of individual polymers) and the influence of relevant functional properties of chitosans (e.g., molecular weight, degree of deacetylation, and viscosity) on this process. The chapter discusses in detail the overall effect of chitosan-based PECs on morphology, encapsulation efficiency, stability, and drug release properties of anionic-based particulate drug carriers. Finally, a brief overview of various physicochemical and biopharmaceutical techniques that can be applied for characterization of these complexes and related particulate drug carriers is presented.", publisher = "Wiley", journal = "Advanced Theranostics Materials", booktitle = "Chitosan-based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers", pages = "235-270", doi = "10.1002/9781118998922.ch9" }
Čalija, B., Cekić, N.,& Milić, J.. (2015). Chitosan-based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers. in Advanced Theranostics Materials Wiley., 235-270. https://doi.org/10.1002/9781118998922.ch9
Čalija B, Cekić N, Milić J. Chitosan-based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers. in Advanced Theranostics Materials. 2015;:235-270. doi:10.1002/9781118998922.ch9 .
Čalija, Bojan, Cekić, Nebojša, Milić, Jela, "Chitosan-based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers" in Advanced Theranostics Materials (2015):235-270, https://doi.org/10.1002/9781118998922.ch9 . .