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dc.creatorMasana, M
dc.creatorJukić, Marin
dc.creatorKretzschmar, A
dc.creatorWagner, K.V
dc.creatorWesterholz, S
dc.creatorSchmidt, M.V
dc.creatorRein, T
dc.creatorBrodski, C
dc.creatorMüller, M.B
dc.date.accessioned2019-09-02T11:49:33Z
dc.date.available2019-09-02T11:49:33Z
dc.date.issued2015
dc.identifier.issn0306-4522
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2496
dc.description.abstractUnderstanding the molecular mechanisms that promote stress resilience might open up new therapeutic avenues to prevent stress-related disorders. We recently characterized a stress and glucocorticoid-regulated gene, down-regulated in renal cell carcinoma - DRR1 (Fam107A). DRR1 is expressed in the mouse brain; it is up-regulated by stress and glucocorticoids and modulates neuronal actin dynamics. In the adult mouse, DRR1 was shown to facilitate specific behaviors which might be protective against some of the deleterious consequences of stress exposure: in the hippocampal CA3 region, DRR1 improved cognitive performance whereas in the septum, it specifically increased social behavior. Therefore DRR1 was suggested as a candidate protein promoting stress-resilience.Fam107B (family with sequence similarity 107, member B) is the unique paralog of DRR1, and both share high sequence similarities, predicted glucocorticoid response elements, heat-shock induction and tumor suppressor properties. So far, the role of Fam107B in the central nervous system was not studied. The aim of the present investigation, therefore, was to analyze whether Fam107B and DRR1 display comparable mRNA expression patterns in the brain and whether both are modulated by stress and glucocorticoids.Spatio-temporal mapping of Fam107B mRNA expression in the embryonic and adult mouse brain, by means of in situ hybridization, showed that Fam107B was expressed during embryogenesis and in the adulthood, with particularly high and specific expression in the forming telencephalon suggestive of an involvement in corticogenesis. In the adult mouse, expression was restricted to neurogenic niches, like the dentate gyrus. In contrast to DRR1, Fam107B mRNA expression failed to be modulated by glucocorticoids and social stress in the adult mouse.In summary, Fam107B and DRR1 show different spatio-temporal expression patterns in the central nervous system, suggesting at least partially different functional roles in the brain, and where the glucocorticoid receptor (GR)-induced regulation appears to be a unique property of DRR1.en
dc.publisherElsevier Ltd
dc.relationIsraeli Science Foundation (C.B. grant 1391/11 )
dc.rightsrestrictedAccess
dc.sourceNeuroscience
dc.subjectCorticogenesisen
dc.subjectDRR1 - Fam107A - Tu3Aen
dc.subjectFam107B - HITSen
dc.subjectGlucocorticoid receptoren
dc.subjectStressen
dc.titleDeciphering the spatio-temporal expression and stress regulation of Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse brainen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМüллер, М.Б; Јукић, Марин; Бродски, Ц; Масана, М; Кретзсцхмар, A; Wагнер, К.В; Wестерхолз, С; Сцхмидт, М.В; Реин, Т;
dc.citation.volume290
dc.citation.spage147
dc.citation.epage158
dc.citation.other290: 147-158
dc.citation.rankM22
dc.identifier.wos000350979300014
dc.identifier.doi10.1016/j.neuroscience.2015.01.026
dc.identifier.scopus2-s2.0-84922385911
dc.type.versionpublishedVersion


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