Liquid chromatography is the most widely used analytical technique in course of research and development, as well as for routine investigation and quality control of pharmaceutical products. Having in mind the remarkable amount of waist resulting from the use of organic solvents, especially for reversed-phase liquid chromatography, recently ecologically acceptable concepts in chromatographic method development were noticed. The 3 Rrule (Reduce - Replace - Recycle) refers to the decrease of the toxic solvents use, their replacement with less toxic ones and the use of renewable solvents. This paper presents different solutions commonly applied in drug analysis that are in accordance with the 3 Rrule.
Tečna hromatografija predstavlja najčešće korišćenu analitičku tehniku tokom istraživanja i razvoja, kao i u rutinskom ispitivanju i kontroli kvaliteta farmaceutskih proizvoda. Imajući u vidu značajnu količinu otpada koji potiče od upotrebljenih organskih rastvarača, naročito kod reverzno-fazne tečne hromatografije, zabeleženi su novi koncepti razvoja ekološki prihvatljive hromatografske metode. Pravilo 3 R (eng. Reduce - Replace - Recycle) podrazumeva smanjenu upotrebu toksičnih rastvarača, njihovu zamenu manje toksičnim rastvaračima, kao i rastvaračima koji se mogu prerađivati. U ovom radu su predstavljena različita rešenja koja zadovoljavaju 3 R pravila i često se primenjuju u analitici lekova.
Keywords:
drug analysis / liquid chromatography / the use of organic solvents / ecologically acceptable solutions / analitika lekova / tečna hromatografija / upotreba organskih rastvarača / ekološki prihvatljiva rešenja
TY - JOUR
AU - Otašević, Biljana
AU - Protić, Ana
AU - Golubović, Jelena
AU - Zečević, Mira
PY - 2015
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2497
AB - Liquid chromatography is the most widely used analytical technique in course of research and development, as well as for routine investigation and quality control of pharmaceutical products. Having in mind the remarkable amount of waist resulting from the use of organic solvents, especially for reversed-phase liquid chromatography, recently ecologically acceptable concepts in chromatographic method development were noticed. The 3 Rrule (Reduce - Replace - Recycle) refers to the decrease of the toxic solvents use, their replacement with less toxic ones and the use of renewable solvents. This paper presents different solutions commonly applied in drug analysis that are in accordance with the 3 Rrule.
AB - Tečna hromatografija predstavlja najčešće korišćenu analitičku tehniku tokom istraživanja i razvoja, kao i u rutinskom ispitivanju i kontroli kvaliteta farmaceutskih proizvoda. Imajući u vidu značajnu količinu otpada koji potiče od upotrebljenih organskih rastvarača, naročito kod reverzno-fazne tečne hromatografije, zabeleženi su novi koncepti razvoja ekološki prihvatljive hromatografske metode. Pravilo 3 R (eng. Reduce - Replace - Recycle) podrazumeva smanjenu upotrebu toksičnih rastvarača, njihovu zamenu manje toksičnim rastvaračima, kao i rastvaračima koji se mogu prerađivati. U ovom radu su predstavljena različita rešenja koja zadovoljavaju 3 R pravila i često se primenjuju u analitici lekova.
PB - Savez farmaceutskih udruženja Srbije, Beograd
T2 - Arhiv za farmaciju
T1 - The application of ecologically acceptable concept in liquid chromatographic method development in drug analyses
T1 - Primena koncepta razvoja ekološki prihvatljivih metoda tečne hromatografije u analitici lekova
VL - 65
IS - 3
SP - 178
EP - 190
DO - 10.5937/arhfarm1503178O
ER -
@article{
author = "Otašević, Biljana and Protić, Ana and Golubović, Jelena and Zečević, Mira",
year = "2015",
abstract = "Liquid chromatography is the most widely used analytical technique in course of research and development, as well as for routine investigation and quality control of pharmaceutical products. Having in mind the remarkable amount of waist resulting from the use of organic solvents, especially for reversed-phase liquid chromatography, recently ecologically acceptable concepts in chromatographic method development were noticed. The 3 Rrule (Reduce - Replace - Recycle) refers to the decrease of the toxic solvents use, their replacement with less toxic ones and the use of renewable solvents. This paper presents different solutions commonly applied in drug analysis that are in accordance with the 3 Rrule., Tečna hromatografija predstavlja najčešće korišćenu analitičku tehniku tokom istraživanja i razvoja, kao i u rutinskom ispitivanju i kontroli kvaliteta farmaceutskih proizvoda. Imajući u vidu značajnu količinu otpada koji potiče od upotrebljenih organskih rastvarača, naročito kod reverzno-fazne tečne hromatografije, zabeleženi su novi koncepti razvoja ekološki prihvatljive hromatografske metode. Pravilo 3 R (eng. Reduce - Replace - Recycle) podrazumeva smanjenu upotrebu toksičnih rastvarača, njihovu zamenu manje toksičnim rastvaračima, kao i rastvaračima koji se mogu prerađivati. U ovom radu su predstavljena različita rešenja koja zadovoljavaju 3 R pravila i često se primenjuju u analitici lekova.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The application of ecologically acceptable concept in liquid chromatographic method development in drug analyses, Primena koncepta razvoja ekološki prihvatljivih metoda tečne hromatografije u analitici lekova",
volume = "65",
number = "3",
pages = "178-190",
doi = "10.5937/arhfarm1503178O"
}
Otašević, B., Protić, A., Golubović, J.,& Zečević, M.. (2015). The application of ecologically acceptable concept in liquid chromatographic method development in drug analyses. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 65(3), 178-190.
https://doi.org/10.5937/arhfarm1503178O
Otašević B, Protić A, Golubović J, Zečević M. The application of ecologically acceptable concept in liquid chromatographic method development in drug analyses. in Arhiv za farmaciju. 2015;65(3):178-190.
doi:10.5937/arhfarm1503178O .
Otašević, Biljana, Protić, Ana, Golubović, Jelena, Zečević, Mira, "The application of ecologically acceptable concept in liquid chromatographic method development in drug analyses" in Arhiv za farmaciju, 65, no. 3 (2015):178-190,
https://doi.org/10.5937/arhfarm1503178O . .
