Due to the unceasing progress in design of novel emulsifiers, powerful influence of the ongoing ‘green’ trends in cosmetic industry, but also global environmental concerns, there is an increasing demand in development and application of natural-origin, biodegradable and skin-friendly emulsifiers. The present work aims to provide a deeper insight into the group of alkyl polyglucoside emulsifiers and their prospective impact on drug percutaneous permeation. Complexity of the observed lamellar liquid crystal and lamellar gel phases, which represent the basic mechanism of physical stabilisation by the alkyl polyglucosides, entails a comprehensive physicochemical evaluation of any alkyl polyglucoside-based prospective vehicle, prior to assessing its impact on skin absorption. Research conducted so far has suggested several possible mechanisms of alkyl polyglucoside-mediated percutaneous penetration enhancement, which are carefully elaborated throughout the chapter: (1) the observed similari...ty between the aforementioned complex structures which dominate alkyl polyglucoside-stabilised systems and the inherent stratum corneum lipid ordering could enhance penetration due to the optimal balance between their order and fluidity, (2) the observed complex colloidal structure may lead to diverse modes of water distribution within these systems, providing sustained skin hydration and hence improved skin permeability, and/or (3) the impact on a drug’s thermodynamic activity, easily tailored by the addition of various co-solvents/potential penetration enhancers.
TY - CHAP
AU - Pantelić, Ivana
AU - Milić, Jela
AU - Vuleta, Gordana
AU - Dragičević, Nina
AU - Savić, Snežana
PY - 2015
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2506
AB - Due to the unceasing progress in design of novel emulsifiers, powerful influence of the ongoing ‘green’ trends in cosmetic industry, but also global environmental concerns, there is an increasing demand in development and application of natural-origin, biodegradable and skin-friendly emulsifiers. The present work aims to provide a deeper insight into the group of alkyl polyglucoside emulsifiers and their prospective impact on drug percutaneous permeation. Complexity of the observed lamellar liquid crystal and lamellar gel phases, which represent the basic mechanism of physical stabilisation by the alkyl polyglucosides, entails a comprehensive physicochemical evaluation of any alkyl polyglucoside-based prospective vehicle, prior to assessing its impact on skin absorption. Research conducted so far has suggested several possible mechanisms of alkyl polyglucoside-mediated percutaneous penetration enhancement, which are carefully elaborated throughout the chapter: (1) the observed similarity between the aforementioned complex structures which dominate alkyl polyglucoside-stabilised systems and the inherent stratum corneum lipid ordering could enhance penetration due to the optimal balance between their order and fluidity, (2) the observed complex colloidal structure may lead to diverse modes of water distribution within these systems, providing sustained skin hydration and hence improved skin permeability, and/or (3) the impact on a drug’s thermodynamic activity, easily tailored by the addition of various co-solvents/potential penetration enhancers.
PB - Springer Berlin Heidelberg
T2 - Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the
T1 - Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs
SP - 231
EP - 250
DO - 10.1007/978-3-662-47039-8_14
ER -
@inbook{
author = "Pantelić, Ivana and Milić, Jela and Vuleta, Gordana and Dragičević, Nina and Savić, Snežana",
year = "2015",
abstract = "Due to the unceasing progress in design of novel emulsifiers, powerful influence of the ongoing ‘green’ trends in cosmetic industry, but also global environmental concerns, there is an increasing demand in development and application of natural-origin, biodegradable and skin-friendly emulsifiers. The present work aims to provide a deeper insight into the group of alkyl polyglucoside emulsifiers and their prospective impact on drug percutaneous permeation. Complexity of the observed lamellar liquid crystal and lamellar gel phases, which represent the basic mechanism of physical stabilisation by the alkyl polyglucosides, entails a comprehensive physicochemical evaluation of any alkyl polyglucoside-based prospective vehicle, prior to assessing its impact on skin absorption. Research conducted so far has suggested several possible mechanisms of alkyl polyglucoside-mediated percutaneous penetration enhancement, which are carefully elaborated throughout the chapter: (1) the observed similarity between the aforementioned complex structures which dominate alkyl polyglucoside-stabilised systems and the inherent stratum corneum lipid ordering could enhance penetration due to the optimal balance between their order and fluidity, (2) the observed complex colloidal structure may lead to diverse modes of water distribution within these systems, providing sustained skin hydration and hence improved skin permeability, and/or (3) the impact on a drug’s thermodynamic activity, easily tailored by the addition of various co-solvents/potential penetration enhancers.",
publisher = "Springer Berlin Heidelberg",
journal = "Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the",
booktitle = "Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs",
pages = "231-250",
doi = "10.1007/978-3-662-47039-8_14"
}
Pantelić, I., Milić, J., Vuleta, G., Dragičević, N.,& Savić, S.. (2015). Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs. in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the
Springer Berlin Heidelberg., 231-250.
https://doi.org/10.1007/978-3-662-47039-8_14
Pantelić I, Milić J, Vuleta G, Dragičević N, Savić S. Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs. in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the. 2015;:231-250.
doi:10.1007/978-3-662-47039-8_14 .
Pantelić, Ivana, Milić, Jela, Vuleta, Gordana, Dragičević, Nina, Savić, Snežana, "Natural emulsifiers of the alkyl polyglucoside type and their influence on the permeation of drugs" in Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the (2015):231-250,
https://doi.org/10.1007/978-3-662-47039-8_14 . .
