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Gljive i Helicobacter pylori infekcija

dc.creatorKolundžić, Marina
dc.creatorKundaković, Tatjana
dc.date.accessioned2019-09-02T11:50:01Z
dc.date.available2019-09-02T11:50:01Z
dc.date.issued2015
dc.identifier.issn0018-6872
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2513
dc.description.abstractHelicobacter pylori is a Gram-negative bacterium that colonizes the stomach almost half the world's population. Infection of the stomach with this bacteria leads to chronic gastritis and peptic ulcer disease. Further, long infection with H. pylori can cause the development of gastric cancer disease. Therefore, the eradication of H. pylori is very important, but it is difficult because the resistance to the antibiotic regimes, especially metronidazole and clarithromycin increases. Therefore, the compounds with antimicrobial activity but not antibiotics are very important in the treatment of H. pylori infections, especially if they have an effect on H. pylori strains resistant to antibiotics. Plants and fungi are a very important source of compounds with antimicrobial activity. Previous studies have shown that fungi such as Pseudonocardia sp. CL38489, Phanerochaete velutina CL6387, Hericium erinaceus, Fomes fomentarius and Antrodia camphorata can be an important source of compounds with activity against H. pylori. Different groups of chemical compounds may be responsible for manifested antibacterial activity, including phenols and beta-glucans. In addition to antibacterial activity, an important mechanism of action against the bacterium H. pylori is the inhibition of the adhesion of bacteria to the gastric epithelium.en
dc.description.abstractHelicobacter pylori je Gram negativna bakterija koja kolonizira želudac skoro polovine svetske populacije. Infekcija želuca ovom bakterijom dovodi do hroničnog gastritisa i peptičkog ulkusa. Duga infekcija bakterijom H. pylori može da dovede do razvoja gastričnog kancera. Zbog toga je eradikacija H. pylori veoma važna, ali je otežana jer se rezistencija na antibiotoke, posebno metronidazol i klaritromicin, povećava. Zbog toga su jedinjenja sa antimikrobnim delovanjem koja nisu antibiotici veoma važna u tretmanu H. pylori infekcije, naročito ukoliko deluju na H. pylori sojeve koji su rezistentni na antibiotike. Biljke i gljive predstavljaju veoma važne izvore jedinjenja sa antimikrobnim delovanjem. Dosadašnja istraživanja gljiva, pokazala su da gljive Pseudonocardia sp. CL38489, Phanerochaete velutina CL6387, Hericium erinaceus, Fomes fomentarius i Antrodia camphorata mogu biti značajan izvor jedinjenja sa aktivnošću protiv bakterije H. pylori. Različite grupe hemijskih jedinjenja mogu biti odgovorne za ispoljenu antibakterijsku aktivnost, uključujući fenole i beta-glukane. Pored antibakterijske aktivnosti, značajan mehanizam delovanja sastojaka pečuraka protiv bakterije H. pylori je i inhibicija adhezije bakterije za gastrični epitel.sr
dc.publisherDruštvo za ishranu Srbije, Beograd
dc.rightsopenAccess
dc.sourceHrana i ishrana
dc.subjectHelicobacter pylorien
dc.subjectfungien
dc.subjectHelicobacter pylorisr
dc.subjectgljivesr
dc.titleFungi and Helicobacter pylori infectionen
dc.titleGljive i Helicobacter pylori infekcijasr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКундаковић, Татјана; Колунджић, Марија;
dc.citation.volume56
dc.citation.issue1
dc.citation.spage6
dc.citation.epage11
dc.citation.other56(1): 6-11
dc.citation.rankM52
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1188/2511.pdf
dc.identifier.rcubconv_629
dc.type.versionpublishedVersion


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