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Resistin, inflammation and dyslipidemia in obese children and adolescents
Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata
dc.creator | Pavlović, Branko | |
dc.creator | Milosavljević, Jovana | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Vekić, Jelena | |
dc.creator | Joksić, Jelena | |
dc.creator | Sopić, Miron | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Paripović, Dušan | |
dc.creator | Peco-Antić, Amira | |
dc.creator | Miloševski-Lomić, Gordana | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.date.accessioned | 2019-09-02T11:50:02Z | |
dc.date.available | 2019-09-02T11:50:02Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0004-1963 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2514 | |
dc.description.abstract | Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk. | en |
dc.description.abstract | Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji. | sr |
dc.publisher | Savez farmaceutskih udruženja Srbije, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175079/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Arhiv za farmaciju | |
dc.subject | childhood obesity | en |
dc.subject | resistin | en |
dc.subject | inflammation | en |
dc.subject | dyslipidemia | en |
dc.subject | dečja gojaznost | sr |
dc.subject | rezistin | sr |
dc.subject | inflamacija | sr |
dc.subject | dislipidemija | sr |
dc.title | Resistin, inflammation and dyslipidemia in obese children and adolescents | en |
dc.title | Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata | sr |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Јелић-Ивановић, Зорана; Милосављевић, Јована; Сопић, Мирон; Пецо-Aнтић, Aмира; Париповић, Душан; Јоксић, Јелена; Милошевски-Ломић, Гордана; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Векић, Јелена; Павловић, Бранко; Резистин, инфламација и дислипидемија код гојазне деце и адолесцената; Резистин, инфламација и дислипидемија код гојазне деце и адолесцената; | |
dc.citation.volume | 65 | |
dc.citation.issue | 2 | |
dc.citation.spage | 115 | |
dc.citation.epage | 128 | |
dc.citation.other | 65(2): 115-128 | |
dc.citation.rank | M53 | |
dc.identifier.doi | 10.5937/arhfarm1502115P | |
dc.identifier.scopus | 2-s2.0-84971597434 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1189/2512.pdf | |
dc.type.version | publishedVersion |