Приказ основних података о документу
Chemical composition and biological activity of the plum seed extract
Hemijski sastav i biološka aktivnost ekstrakta semena šljive
dc.creator | Savić, Ivan | |
dc.creator | Nikolić, Vesna D. | |
dc.creator | Savić-Gajić, Ivana | |
dc.creator | Kundaković, Tatjana | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Najman, Stevo J. | |
dc.date.accessioned | 2019-09-02T11:50:26Z | |
dc.date.available | 2019-09-02T11:50:26Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2406-2979 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2529 | |
dc.description.abstract | The aim of this paper was to estimate the biological activity of the plum seed extract and to define the chemical composition by using the ESI-MS method. During the investigation of the antioxidant activity, the extract showed a better ability to inhibit DPPH radicals compared with amygdalin standard. The results of the antimicrobial study indicate that the extract has a greater effect on Gram-negative bacteria compared with amygdalin. Gram-positive bacteria and fungi remained resistant in both cases. Unlike amygdalin, the extract showed a greater antimicrobial activity against the same microbiological strains. Amygdalin was isolated from the extract before the investigation of antiproliferative activity against MDA-MB-361, MDA-MB-453, HeLa and LS174 cell lines using MTT assay. Unlike the MDA-MB-453 cell line, the activity of standard and isolated amygdalin was not observed at the concentrations lower than 400 μg cm-3 on MDA-MB-361 cell line. The isolated amygdalin has not shown the activity in other cell lines. The antiproliferative activity of amygdalin standard was also noticed on HeLa and LS-174 cell lines at the concentrations of 333.27 and 333.17 μg cm-3, respectively. | en |
dc.description.abstract | Cilj ovog rada bila je procena biološke aktivnosti ekstrakta semena šljive i definisanje hemijskog sastava primenom ESI-MS metode. Tokom ispitivanja antioksidativne aktivnosti, ekstrakt je pokazao bolju sposobnost inhibiranja DPPH radikala u poređenju sa standardom amigdalina. Rezultati antimikrobne studije pokazali su da ekstrakt ima veći uticaj na rast Gram-negativnih bakterija u odnosnu na amigdalin. Gram-pozitivne bakterije i gljivice ostale su rezistentne u oba slučaja. Za razliku od amigdalina, ekstrakt je pokazao veću antimikrobnu aktivnost na iste sojeve mikroorganizama. Amigdalin je izolovan iz ekstrakta pre ispitivanja antiproliferativne aktivnosti na MDA-MB-361, MDA-MB-453, HeLa i LS174 ćelijskim linijama upotrebom MTT testa. Za razliku od MDA-MB-453 ćelijskih linija, aktivnost standarda i izolovanog amigdalina nije uočena na MDA-MB-361 ćelijskim linijama pri koncentracijama nižim od 400 μg cm-3. Izolovani amigdalin nije pokazao aktivnost na ostalim ćelijskim linijama. Antiproliferativna aktivnost standarda amigdalina uočena je i na HeLa i LS-174 ćelijskim linijama pri koncentracijama 333.27 i 333.17 μg cm-3, respektivno. | sr |
dc.publisher | Univerzitet u Nišu - Tehnološki fakultet, Leskovac | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34012/RS// | |
dc.rights | openAccess | |
dc.source | Advanced Technologies | |
dc.subject | plum seeds | en |
dc.subject | amygdalin | en |
dc.subject | antioxidant activity | en |
dc.subject | antimicrobial activity | en |
dc.subject | antiproliferative activity | en |
dc.subject | seme šljive | sr |
dc.subject | amigdalin | sr |
dc.subject | antioksidativna aktivnost | sr |
dc.subject | antimikrobna aktivnost | sr |
dc.subject | antiproliferativna aktivnost | sr |
dc.title | Chemical composition and biological activity of the plum seed extract | en |
dc.title | Hemijski sastav i biološka aktivnost ekstrakta semena šljive | sr |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Најман, Стево Ј.; Николић, Весна Д.; Станојковић, Татјана; Савић, Иван М.; Савић-Гајић, Ивана; Кундаковић, Татјана; Хемијски састав и биолошка активност екстракта семена шљиве; Хемијски састав и биолошка активност екстракта семена шљиве; | |
dc.citation.volume | 5 | |
dc.citation.issue | 2 | |
dc.citation.spage | 38 | |
dc.citation.epage | 45 | |
dc.citation.other | 5(2): 38-45 | |
dc.citation.rank | M52 | |
dc.identifier.doi | 10.5937/savteh1602038S | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1203/2527.pdf | |
dc.type.version | publishedVersion |