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dc.creatorTrbojević, Jovana B.
dc.creatorOdović, Jadranka
dc.creatorTrbojević-Stanković, Jasna
dc.creatorNešić, Dejan M.
dc.creatorJelić, Ratomir
dc.date.accessioned2019-09-02T11:50:35Z
dc.date.available2019-09-02T11:50:35Z
dc.date.issued2016
dc.identifier.issn0354-4664
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2536
dc.description.abstractIn the present study, we investigated the relationships between several molecular properties and bioavailability data for seven of the most commonly prescribed angiotensin II receptor antagonists (also known as angiotensin II receptor blockers (ARBs) or sartans), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan and valsartan. The molecular descriptors of ARBs are:, aqueous solubility (logS values), polar surface area (PSA), molecular weight (Mw), volume value (Vol), lipophilicity (logP values) and the acidity descriptor (pK(a1)). The respective descriptors were calculated using four different software packages. The relevant bioavailability data were obtained from literature. Among calculated molecular descriptors, simple linear regression analysis showed the best correlation between bioavailability data and the lipophilicity descriptor, logP (R-2 = 0.568). Multiple linear regression established good correlations between bioavailability and the lipophilicity descriptor, logP, using the molecular weight, Mw, or the acidity descriptor, pK(a1), as an additional, independent variable (with R-2 = 0.661 and 0.682, respectively). Finally, excluding candesartan from the calculations resulted in a very good correlation (R-2 = 0.852) between the remaining ARB bioavailability and molecular descriptors MlogP and Mw as independent variables, determined by multiple linear regression.en
dc.publisherSrpsko biološko društvo, Beograd, i dr.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsopenAccess
dc.sourceArchives of Biological Sciences
dc.titleRelationship between the bioavailability and molecular properties of angiotensin II receptor antagonistsen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractТрбојевић, Јована Б.; Одовић, Јадранка; Нешић, Дејан М.; Јелић, Ратомир; Трбојевић-Станковић, Јасна;
dc.citation.volume68
dc.citation.issue2
dc.citation.spage273
dc.citation.epage278
dc.citation.other68(2): 273-278
dc.citation.rankM23
dc.identifier.wos000377883900003
dc.identifier.doi10.2298/ABS150915015T
dc.identifier.scopus2-s2.0-84970974472
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1210/2534.pdf
dc.identifier.rcubconv_3594
dc.type.versionpublishedVersion


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