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Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative

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2016
2535.pdf (197.2Kb)
Authors
Dobričić, Vladimir
Vladimirov, Sote
Čudina, Olivera
Article (Published version)
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Abstract
Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.
Keywords:
cortienic acid / amide / lipophilicity / RP-TLC
Source:
Kragujevac Journal of Science, 2016, 38, 107-114
Publisher:
  • Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
Funding / projects:
  • Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-172041)

DOI: 10.5937/KgJSci1638107D

ISSN: 1450-9636

[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2537
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Dobričić, Vladimir
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2537
AB  - Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.
PB  - Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
T2  - Kragujevac Journal of Science
T1  - Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative
IS  - 38
SP  - 107
EP  - 114
DO  - 10.5937/KgJSci1638107D
ER  - 
@article{
author = "Dobričić, Vladimir and Vladimirov, Sote and Čudina, Olivera",
year = "2016",
abstract = "Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.",
publisher = "Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac",
journal = "Kragujevac Journal of Science",
title = "Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative",
number = "38",
pages = "107-114",
doi = "10.5937/KgJSci1638107D"
}
Dobričić, V., Vladimirov, S.,& Čudina, O.. (2016). Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative. in Kragujevac Journal of Science
Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac.(38), 107-114.
https://doi.org/10.5937/KgJSci1638107D
Dobričić V, Vladimirov S, Čudina O. Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative. in Kragujevac Journal of Science. 2016;(38):107-114.
doi:10.5937/KgJSci1638107D .
Dobričić, Vladimir, Vladimirov, Sote, Čudina, Olivera, "Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative" in Kragujevac Journal of Science, no. 38 (2016):107-114,
https://doi.org/10.5937/KgJSci1638107D . .

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