Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.
Keywords:
cortienic acid / amide / lipophilicity / RP-TLC
Source:
Kragujevac Journal of Science, 2016, 38, 107-114
Publisher:
Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
TY - JOUR
AU - Dobričić, Vladimir
AU - Vladimirov, Sote
AU - Čudina, Olivera
PY - 2016
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2537
AB - Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.
PB - Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
T2 - Kragujevac Journal of Science
T1 - Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative
IS - 38
SP - 107
EP - 114
DO - 10.5937/KgJSci1638107D
ER -
@article{
author = "Dobričić, Vladimir and Vladimirov, Sote and Čudina, Olivera",
year = "2016",
abstract = "Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.",
publisher = "Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac",
journal = "Kragujevac Journal of Science",
title = "Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative",
number = "38",
pages = "107-114",
doi = "10.5937/KgJSci1638107D"
}
Dobričić, V., Vladimirov, S.,& Čudina, O.. (2016). Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative. in Kragujevac Journal of Science
Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac.(38), 107-114.
https://doi.org/10.5937/KgJSci1638107D
Dobričić V, Vladimirov S, Čudina O. Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative. in Kragujevac Journal of Science. 2016;(38):107-114.
doi:10.5937/KgJSci1638107D .
Dobričić, Vladimir, Vladimirov, Sote, Čudina, Olivera, "Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative" in Kragujevac Journal of Science, no. 38 (2016):107-114,
https://doi.org/10.5937/KgJSci1638107D . .
