Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative
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Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.
Keywords:cortienic acid / amide / lipophilicity / RP-TLC
Source:Kragujevac Journal of Science, 2016, 38, 107-114
- Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
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