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Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative

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2016
2535.pdf (197.2Kb)
Authors
Dobričić, Vladimir
Vladimirov, Sote
Čudina, Olivera
Article (Published version)
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Abstract
Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid.
Keywords:
cortienic acid / amide / lipophilicity / RP-TLC
Source:
Kragujevac Journal of Science, 2016, 38, 107-114
Publisher:
  • Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
Projects:
  • Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-172041)

DOI: 10.5937/KgJSci1638107D

ISSN: 1450-9636

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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2537
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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