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dc.creatorKovacević, Jovana
dc.creatorIbrić, Svetlana
dc.creatorĐuriš, Jelena
dc.creatorKleinebudde, Peter
dc.date.accessioned2019-09-02T11:50:48Z
dc.date.available2019-09-02T11:50:48Z
dc.date.issued2016
dc.identifier.issn0378-5173
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2543
dc.description.abstractThis study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to process efficency and useful yield were determined. Results of experiments showed that formulation characteristics were the ones with the greatest impact on coating efficiency and that suspension layering technique was significantly better for drug application onto inactive pellets in comparison to solution layering during which pronounced agglomeration of pellets occurred. Analysis of drug-polymer interactions by differential scanning calorimetry was performed to explain the results of experiments. The reason for agglomeration of pellets during solution layering was formation of low Tg amorphous form of model drug. The second set of experiments was performed according to central composite design experimental plan in order to optimize level of binder and concentration of solids in the coating liquid which were found to have greatest positive impact on process efficiency and useful yield in the screening study. Statistically significant models were obtained by response surface methodology and it was possible to use them to define optimal levels of excipients in the formulation.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.titleApplication of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂуриш, Јелена; Клеинебудде, Петер; Ибрић, Светлана; Ковацевић, Јована;
dc.citation.volume506
dc.citation.issue1-2
dc.citation.spage312
dc.citation.epage319
dc.citation.other506(1-2): 312-319
dc.citation.rankM21
dc.identifier.wos000377031200033
dc.identifier.doi10.1016/j.ijpharm.2016.04.030
dc.identifier.pmid27094356
dc.identifier.scopus2-s2.0-84964910529
dc.type.versionpublishedVersion


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