Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus

2016
Authors
Kangrga, RankaIgnjatović, Svetlana

Dragasević, Mirjana M.
Jovičić, Snežana

Majkić-Singh, Nada
Article (Published version)

Metadata
Show full item recordAbstract
Objective: The measurement of pancreatic elastase (PE) in feces is used widely to screen for pancreatic exocrine insufficiency. The aim of our study was to evaluate the relationship of PE with residual beta cell secretion and metabolic control in patients with diabetes mellitus. Method: We determined the presence of PE in specimens via enzyme-linked immunosorbent assay (ELISA), whereas serum fasting glucose, C-peptide, amylase, lipase, triglycerides, total 25(OH)-vitamin D, C-reactive protein (CRP), and hemoglobin A(1c) (HbA(1c)) concentrations were assayed using routine laboratory tests. Results: PE values in 48 patients with diabetes were significantly lower than in 24 healthy volunteers (P = .001). In one-third of participants with diabetes mellitus, PE were less than 200 mu g per g, indicating pancreatic functional insufficiency. Among the patients in the cohort, PE correlated positively with C-peptide levels (P = .04), lipase (P = .009), CRP (P = .04), sex (P = .03), and BMI (P = ....02) but not significantly with duration of diabetes (P = .81) or levels of HbA(1c) (P = .87), amylase (P = .06), total 25(OH)-vitamin D (P = .16), or triglycerides (P = .52). Conclusion: Our results demonstrated a strong association of diabetes with low PE levels.
Source:
Labmedicine, 2016, 47, 2, 140-148Publisher:
- Oxford Univ Press, Oxford
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.1093/labmed/lmw015
ISSN: 0007-5027
PubMed: 27069032
WoS: 000376651200011
Scopus: 2-s2.0-85018334937
Collections
Institution/Community
PharmacyTY - JOUR AU - Kangrga, Ranka AU - Ignjatović, Svetlana AU - Dragasević, Mirjana M. AU - Jovičić, Snežana AU - Majkić-Singh, Nada PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2546 AB - Objective: The measurement of pancreatic elastase (PE) in feces is used widely to screen for pancreatic exocrine insufficiency. The aim of our study was to evaluate the relationship of PE with residual beta cell secretion and metabolic control in patients with diabetes mellitus. Method: We determined the presence of PE in specimens via enzyme-linked immunosorbent assay (ELISA), whereas serum fasting glucose, C-peptide, amylase, lipase, triglycerides, total 25(OH)-vitamin D, C-reactive protein (CRP), and hemoglobin A(1c) (HbA(1c)) concentrations were assayed using routine laboratory tests. Results: PE values in 48 patients with diabetes were significantly lower than in 24 healthy volunteers (P = .001). In one-third of participants with diabetes mellitus, PE were less than 200 mu g per g, indicating pancreatic functional insufficiency. Among the patients in the cohort, PE correlated positively with C-peptide levels (P = .04), lipase (P = .009), CRP (P = .04), sex (P = .03), and BMI (P = .02) but not significantly with duration of diabetes (P = .81) or levels of HbA(1c) (P = .87), amylase (P = .06), total 25(OH)-vitamin D (P = .16), or triglycerides (P = .52). Conclusion: Our results demonstrated a strong association of diabetes with low PE levels. PB - Oxford Univ Press, Oxford T2 - Labmedicine T1 - Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus VL - 47 IS - 2 SP - 140 EP - 148 DO - 10.1093/labmed/lmw015 ER -
@article{ author = "Kangrga, Ranka and Ignjatović, Svetlana and Dragasević, Mirjana M. and Jovičić, Snežana and Majkić-Singh, Nada", year = "2016", abstract = "Objective: The measurement of pancreatic elastase (PE) in feces is used widely to screen for pancreatic exocrine insufficiency. The aim of our study was to evaluate the relationship of PE with residual beta cell secretion and metabolic control in patients with diabetes mellitus. Method: We determined the presence of PE in specimens via enzyme-linked immunosorbent assay (ELISA), whereas serum fasting glucose, C-peptide, amylase, lipase, triglycerides, total 25(OH)-vitamin D, C-reactive protein (CRP), and hemoglobin A(1c) (HbA(1c)) concentrations were assayed using routine laboratory tests. Results: PE values in 48 patients with diabetes were significantly lower than in 24 healthy volunteers (P = .001). In one-third of participants with diabetes mellitus, PE were less than 200 mu g per g, indicating pancreatic functional insufficiency. Among the patients in the cohort, PE correlated positively with C-peptide levels (P = .04), lipase (P = .009), CRP (P = .04), sex (P = .03), and BMI (P = .02) but not significantly with duration of diabetes (P = .81) or levels of HbA(1c) (P = .87), amylase (P = .06), total 25(OH)-vitamin D (P = .16), or triglycerides (P = .52). Conclusion: Our results demonstrated a strong association of diabetes with low PE levels.", publisher = "Oxford Univ Press, Oxford", journal = "Labmedicine", title = "Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus", volume = "47", number = "2", pages = "140-148", doi = "10.1093/labmed/lmw015" }
Kangrga, R., Ignjatović, S., Dragasević, M. M., Jovičić, S.,& Majkić-Singh, N.. (2016). Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus. in Labmedicine Oxford Univ Press, Oxford., 47(2), 140-148. https://doi.org/10.1093/labmed/lmw015
Kangrga R, Ignjatović S, Dragasević MM, Jovičić S, Majkić-Singh N. Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus. in Labmedicine. 2016;47(2):140-148. doi:10.1093/labmed/lmw015 .
Kangrga, Ranka, Ignjatović, Svetlana, Dragasević, Mirjana M., Jovičić, Snežana, Majkić-Singh, Nada, "Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus" in Labmedicine, 47, no. 2 (2016):140-148, https://doi.org/10.1093/labmed/lmw015 . .