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dc.creatorKangrga, Ranka
dc.creatorIgnjatović, Svetlana
dc.creatorDragasević, Mirjana M.
dc.creatorJovičić, Snežana
dc.creatorMajkić-Singh, Nada
dc.date.accessioned2019-09-02T11:50:50Z
dc.date.available2019-09-02T11:50:50Z
dc.date.issued2016
dc.identifier.issn0007-5027
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2546
dc.description.abstractObjective: The measurement of pancreatic elastase (PE) in feces is used widely to screen for pancreatic exocrine insufficiency. The aim of our study was to evaluate the relationship of PE with residual beta cell secretion and metabolic control in patients with diabetes mellitus. Method: We determined the presence of PE in specimens via enzyme-linked immunosorbent assay (ELISA), whereas serum fasting glucose, C-peptide, amylase, lipase, triglycerides, total 25(OH)-vitamin D, C-reactive protein (CRP), and hemoglobin A(1c) (HbA(1c)) concentrations were assayed using routine laboratory tests. Results: PE values in 48 patients with diabetes were significantly lower than in 24 healthy volunteers (P = .001). In one-third of participants with diabetes mellitus, PE were less than 200 mu g per g, indicating pancreatic functional insufficiency. Among the patients in the cohort, PE correlated positively with C-peptide levels (P = .04), lipase (P = .009), CRP (P = .04), sex (P = .03), and BMI (P = .02) but not significantly with duration of diabetes (P = .81) or levels of HbA(1c) (P = .87), amylase (P = .06), total 25(OH)-vitamin D (P = .16), or triglycerides (P = .52). Conclusion: Our results demonstrated a strong association of diabetes with low PE levels.en
dc.publisherOxford Univ Press, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsopenAccess
dc.sourceLabmedicine
dc.titlePancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitusen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКангрга, Ранка; Јовичић, Снежана; Мајкић-Сингх, Нада; Игњатовић, Светлана; Драгасевић, Мирјана М.;
dc.citation.volume47
dc.citation.issue2
dc.citation.spage140
dc.citation.epage148
dc.citation.other47(2): 140-148
dc.citation.rankM23
dc.identifier.wos000376651200011
dc.identifier.doi10.1093/labmed/lmw015
dc.identifier.pmid27069032
dc.identifier.scopus2-s2.0-85018334937
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1221/2544.pdf
dc.identifier.rcubconv_3582
dc.type.versionpublishedVersion


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