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Multiple Targeting Approaches on Histamine H-3 Receptor Antagonists
dc.creator | Khanfar, Mohammad A. | |
dc.creator | Affini, Anna | |
dc.creator | Lutsenko, Kiril | |
dc.creator | Nikolić, Katarina | |
dc.creator | Butini, Stefania | |
dc.creator | Stark, Holger | |
dc.date.accessioned | 2019-09-02T11:50:52Z | |
dc.date.available | 2019-09-02T11:50:52Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1662-453X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2547 | |
dc.description.abstract | With the very recent market approval of pitolisant (Wakix (R)), the interest in clinical applications of novel multifunctional histamine H-3 receptor antagonists has clearly increased. Since histamine H-3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effects and reduced unwanted side-effects is rationally based on the increasing knowledge on the complex neurotransmitter regulations. The polypharmacological approaches on histamine H-3 receptor antagonists on different G-protein coupled receptors, transporters, enzymes as well as on NO-signaling mechanism are described, supported with some lead structures. | en |
dc.publisher | Frontiers Media Sa, Lausanne | |
dc.relation | EU COST Action CA 15135 | |
dc.relation | EU COST Action CM 1103 | |
dc.relation | EU COST Action CM 1207 | |
dc.relation | DEG - INST 208/664-1 FUGG | |
dc.relation | DEG - Ol16112039 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Frontiers in Neuroscience | |
dc.title | Multiple Targeting Approaches on Histamine H-3 Receptor Antagonists | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Aффини, Aнна; Бутини, Стефаниа; Николић, Катарина; Старк, Холгер; Лутсенко, Кирил; Кханфар, Мохаммад A.; | |
dc.citation.volume | 10 | |
dc.citation.other | 10: - | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000376632300001 | |
dc.identifier.doi | 10.3389/fnins.2016.00201 | |
dc.identifier.pmid | 27303254 | |
dc.identifier.scopus | 2-s2.0-84973575248 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1222/2545.pdf | |
dc.type.version | publishedVersion |