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Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium

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2000
Authors
Đurđević, Predrag
Jelikić-Stankov, Milena
Odović, Jadranka
Article (Published version)
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Abstract
Prototropic equilibria (protonation, hydrolytic and complexation) in iron(III) ion + ciprofloxacin (Hcipx) solutions were studied in 0.1 and 0.5 mol dm(-3) (Na)NO3 ionic media in the absence and in the presence of ionic surfactants: sodium dodecyl sulfate (SDS) or cetyltrimethylammonium bromide (CTAB). Experiments were carried out at 298 +/- 0.2 K using glass electrode potentiometric and UV-Vis spectrophotometric measurements. The concentration of SDS in Fe-III-ciprofloxacin solutions was 10 mmol dm(-3) while that of CTAB was 8 mmol dm(-3). The hydrolysis of the iron(III) ion was studied separately within the concentration range of iron 1-5 mmol dm(-3) and pH 1.6-3.0, Non-linear least-squares treatment of the data indicates that in both ionic media studied the main hydrolytic products were Fe(OH)(2)(+) and Fe-2(OH)(2)(4+). The effect of the concentration of the nitrate ion on the stability constants of these complexes is much more pronounced than the effect of the addition of either SD...S or CTAB. The successive protonation constants of ciprofloxacin anion, cipx(-), relating to the formation of Hcipx and H(2)cipx(+) species, were influenced to a significant extent by the presence of SDS and, to a considerably lesser extent, by the presence of CTAB in both studied concentrations of NO3- ionic media. The complexation between iron(III) and ciprofloxacin was studied in the concentration range of iron(III) 0.15-0.58 mmol dm(-3), with ligand to metal concentration ratios ranging from 3.1 to 10:1 in the pH interval 2.0-6.0. The experimental data obtained could be explained by the formation of mononuclear complexes: Fe(cipx)(2)(+), Fe(cipx)(2+) and Fe(OH)cipx. In the presence of either SDS or CTAB the same complexes were formed; however. much higher formation constants were obtained with SDS. while the effect of CTAB was sluggish. The structure and mechanism of formation of iron (III)-ciprofloxacin complexes in pure ionic and in micellar media are discussed.

Source:
Polyhedron, 2000, 19, 9, 1085-1096
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/S0277-5387(00)00357-0

ISSN: 0277-5387

WoS: 000087690700010

Scopus: 2-s2.0-0034656830
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15
11
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/255
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  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Đurđević, Predrag
AU  - Jelikić-Stankov, Milena
AU  - Odović, Jadranka
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/255
AB  - Prototropic equilibria (protonation, hydrolytic and complexation) in iron(III) ion + ciprofloxacin (Hcipx) solutions were studied in 0.1 and 0.5 mol dm(-3) (Na)NO3 ionic media in the absence and in the presence of ionic surfactants: sodium dodecyl sulfate (SDS) or cetyltrimethylammonium bromide (CTAB). Experiments were carried out at 298 +/- 0.2 K using glass electrode potentiometric and UV-Vis spectrophotometric measurements. The concentration of SDS in Fe-III-ciprofloxacin solutions was 10 mmol dm(-3) while that of CTAB was 8 mmol dm(-3). The hydrolysis of the iron(III) ion was studied separately within the concentration range of iron 1-5 mmol dm(-3) and pH 1.6-3.0, Non-linear least-squares treatment of the data indicates that in both ionic media studied the main hydrolytic products were Fe(OH)(2)(+) and Fe-2(OH)(2)(4+). The effect of the concentration of the nitrate ion on the stability constants of these complexes is much more pronounced than the effect of the addition of either SDS or CTAB. The successive protonation constants of ciprofloxacin anion, cipx(-), relating to the formation of Hcipx and H(2)cipx(+) species, were influenced to a significant extent by the presence of SDS and, to a considerably lesser extent, by the presence of CTAB in both studied concentrations of NO3- ionic media. The complexation between iron(III) and ciprofloxacin was studied in the concentration range of iron(III) 0.15-0.58 mmol dm(-3), with ligand to metal concentration ratios ranging from 3.1 to 10:1 in the pH interval 2.0-6.0. The experimental data obtained could be explained by the formation of mononuclear complexes: Fe(cipx)(2)(+), Fe(cipx)(2+) and Fe(OH)cipx. In the presence of either SDS or CTAB the same complexes were formed; however. much higher formation constants were obtained with SDS. while the effect of CTAB was sluggish. The structure and mechanism of formation of iron (III)-ciprofloxacin complexes in pure ionic and in micellar media are discussed.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Polyhedron
T1  - Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium
VL  - 19
IS  - 9
SP  - 1085
EP  - 1096
DO  - 10.1016/S0277-5387(00)00357-0
ER  - 
@article{
author = "Đurđević, Predrag and Jelikić-Stankov, Milena and Odović, Jadranka",
year = "2000",
abstract = "Prototropic equilibria (protonation, hydrolytic and complexation) in iron(III) ion + ciprofloxacin (Hcipx) solutions were studied in 0.1 and 0.5 mol dm(-3) (Na)NO3 ionic media in the absence and in the presence of ionic surfactants: sodium dodecyl sulfate (SDS) or cetyltrimethylammonium bromide (CTAB). Experiments were carried out at 298 +/- 0.2 K using glass electrode potentiometric and UV-Vis spectrophotometric measurements. The concentration of SDS in Fe-III-ciprofloxacin solutions was 10 mmol dm(-3) while that of CTAB was 8 mmol dm(-3). The hydrolysis of the iron(III) ion was studied separately within the concentration range of iron 1-5 mmol dm(-3) and pH 1.6-3.0, Non-linear least-squares treatment of the data indicates that in both ionic media studied the main hydrolytic products were Fe(OH)(2)(+) and Fe-2(OH)(2)(4+). The effect of the concentration of the nitrate ion on the stability constants of these complexes is much more pronounced than the effect of the addition of either SDS or CTAB. The successive protonation constants of ciprofloxacin anion, cipx(-), relating to the formation of Hcipx and H(2)cipx(+) species, were influenced to a significant extent by the presence of SDS and, to a considerably lesser extent, by the presence of CTAB in both studied concentrations of NO3- ionic media. The complexation between iron(III) and ciprofloxacin was studied in the concentration range of iron(III) 0.15-0.58 mmol dm(-3), with ligand to metal concentration ratios ranging from 3.1 to 10:1 in the pH interval 2.0-6.0. The experimental data obtained could be explained by the formation of mononuclear complexes: Fe(cipx)(2)(+), Fe(cipx)(2+) and Fe(OH)cipx. In the presence of either SDS or CTAB the same complexes were formed; however. much higher formation constants were obtained with SDS. while the effect of CTAB was sluggish. The structure and mechanism of formation of iron (III)-ciprofloxacin complexes in pure ionic and in micellar media are discussed.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Polyhedron",
title = "Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium",
volume = "19",
number = "9",
pages = "1085-1096",
doi = "10.1016/S0277-5387(00)00357-0"
}
Đurđević, P., Jelikić-Stankov, M.,& Odović, J.. (2000). Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium. in Polyhedron
Pergamon-Elsevier Science Ltd, Oxford., 19(9), 1085-1096.
https://doi.org/10.1016/S0277-5387(00)00357-0
Đurđević P, Jelikić-Stankov M, Odović J. Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium. in Polyhedron. 2000;19(9):1085-1096.
doi:10.1016/S0277-5387(00)00357-0 .
Đurđević, Predrag, Jelikić-Stankov, Milena, Odović, Jadranka, "Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium" in Polyhedron, 19, no. 9 (2000):1085-1096,
https://doi.org/10.1016/S0277-5387(00)00357-0 . .

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