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Biofilm formation on tympanostomy tubes depends on methicillin-resistant Staphylococcus aureus genetic lineage

Само за регистроване кориснике
2016
Аутори
Jotić, Ana
Božić, Dragana
Milovanović, Jovica
Pavlović, Bojan
Jesić, Snežana
Pelemis, Mijomir
Novaković, Marko
Cirković, Ivana
Чланак у часопису (Објављена верзија)
Метаподаци
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Апстракт
Bacterial biofilm formation has been implicated in the high incidence of persistent otorrhoea after tympanostomy tube insertion. The aim of the study was to investigate whether biofilm formation on tympanostomy tubes depends on the genetic profile of methicillin-resistant Staphylococcus aureus (MRSA) strains. Capacity of biofilm formation on fluoroplastic tympanostomy tubes (TTs) was tested on 30 MRSA strains. Identification and methicillin resistance were confirmed by PCR for nuc and mecA genes. Strains were genotypically characterised (SCCmec, agr and spa typing). Biofilm formation was tested in microtiter plate and on TTs. Tested MRSA strains were classified into SCCmec type I (36.7 %), III (23.3 %), IV (26.7 %) and V (13.3 %), agr type I (50 %), II (36.7 %) and III (13.3 %), and 5 clonal complexes (CCs). All tested MRSA strains showed ability to form biofilm on microtiter plate. Capacity of biofilm formation on TTs was as following: 13.3 % of strains belonged to the category of no ...biofilm producers, 50 % to the category of weak biofilm producers and 36.7 % to moderate biofilm producers. There was a statistically significant difference between CC, SCCmec and agr types and the category of biofilm production on TTs tubes (p lt 0.001): CC5, SCCmecI type and agrII type with a moderate amount of biofilm, and CC8 and agrI type with a low amount of biofilm. Biofilm formation by MRSA on TTs is highly dependent on genetic characteristics of the strains. Therefore, MRSA genotyping may aid the determination of the possibility of biofilm-related post-tympanostomy tube otorrhea.

Извор:
European Archives of Oto-Rhino-Laryngology, 2016, 273, 3, 615-620
Издавач:
  • Springer, New York
Пројекти:
  • Бактерије резистентне на антибиотике у Србији: фенотипска и генотипска карактеризација (RS-175039)

DOI: 10.1007/s00405-015-3607-8

ISSN: 0937-4477

PubMed: 25796207

WoS: 000371063700013

Scopus: 2-s2.0-84959138728
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2561
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

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