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dc.creatorStanojević, Ivan
dc.creatorMiller, Karolina
dc.creatorKandolf-Sekulović, Lidija
dc.creatorMijušković, Željko
dc.creatorZolotarevska, Lidija
dc.creatorJović, Milena
dc.creatorGacević, Milomir
dc.creatorĐukić, Mirjana
dc.creatorArsenijević, Nebojša
dc.creatorVojvodić, Danilo
dc.date.accessioned2019-09-02T11:51:22Z
dc.date.available2019-09-02T11:51:22Z
dc.date.issued2016
dc.identifier.issn0953-8178
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2565
dc.description.abstractSeventy-eight melanoma patients and 10 healthy individuals were examined. Follow-up examinations of all melanoma patients were performed regularly every three months. Myeloid-derived suppressor cells (MDSC) were defined as lineage negative (CD3(-), CD19(-), CD56(-)), HLA-DR-/low, CD11b(+) and CD33(+). Classification of granulocytic (GrMDSC) and monocytic (MoMDSC) subsets was based on the CD15 and CD14 expression, respectively. Unlike the MoMDSC, that were present in 60% of healthy controls and 15% of melanoma patients, the GrMDSC were present in all examined participants, and the melanoma patients were found to have statistically higher frequencies compared with healthy controls. Accordingly, we kept focused on GrMDSC frequencies in relation to the melanoma stages and course of the disease. The GrMDSC values are highest in stage IV melanoma patients, with statistical significance compared with stages IA, IB, IIA and IIB. Patients with progression had statistically higher GrMDSC counts comparing with those with stable disease (P = 0.0079). Patients who had progression-free interval (PFI) lt 12 months showed significantly higher GrMDSC values compared with those with PFI > 12 months (P = 0.0333). GrMDSC showed significant negative correlation with PFI intervals (P = 0.0095). The GrMDSC subset was predominant in all our patients. We confirmed that GrMDSC do accumulate early in the peripheral blood of melanoma patients and their frequencies correlate narrowly with the clinical stage and the spread of the disease. The increase in GrMDSC frequencies correlates well with a progressive disease and could be considered a potential predictive biomarker of high-risk melanoma cases that are more likely to have a shorter PFI.en
dc.publisherOxford Univ Press, Oxford
dc.relationMinistry of Defense of the Republic of Serbia (Project no. MFVMA/3/13-15)
dc.rightsopenAccess
dc.sourceInternational Immunology
dc.titleA subpopulation that may correspond to granulocytic myeloid-derived suppressor cells reflects the clinical stage and progression of cutaneous melanomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГацевић, Миломир; Ђукић, Мирјана; Станојевић, Иван; Војводић, Данило; Мијушковић, Жељко; Золотаревска, Лидија; Јовић, Милена; Миллер, Каролина; Aрсенијевић, Небојша; Кандолф-Секуловић, Лидија;
dc.citation.volume28
dc.citation.issue2
dc.citation.spage87
dc.citation.epage97
dc.citation.other28(2): 87-97
dc.citation.rankM22
dc.identifier.wos000370298100004
dc.identifier.doi10.1093/intimm/dxv053
dc.identifier.pmid26391013
dc.identifier.scopus2-s2.0-84961800760
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1242/2563.pdf
dc.identifier.rcubconv_3489
dc.type.versionpublishedVersion


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