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Combined application of mixture experimental design and artificial neural networks in the solid dispersion development

Authorized Users Only
2016
Authors
Medarević, Đorđe
Kleinebudde, Peter
Đuriš, Jelena
Đurić, Zorica
Ibrić, Svetlana
Article (Published version)
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Abstract
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus (R)-poloxamer 188 SDs were prepared by solvent casting method to improve carbamazepine dissolution rate. The influence of the composition of prepared SDs on carbamazepine dissolution rate was evaluated using d-optimal mixture experimental design and multilayer perceptron ANNs. Physicochemical characterization proved the presence of the most stable carbamazepine polymorph III within the SD matrix. Ternary carbamazepine-Soluplus (R)-poloxamer 188 SDs significantly improved carbamazepine dissolution rate compared to pure drug. Models developed by ANNs and mixture experimental design well described the relationship between proportions of SD components and percentage of carbamazepine released after 10 (Q(10)) and 20 (Q(20)) min, wherein ANN model exhibit better predictability on test da...ta set. Proportions of carbamazepine and poloxamer 188 exhibited the highest influence on carbamazepine release rate. The highest carbamazepine release rate was observed for SDs with the lowest proportions of carbamazepine and the highest proportions of poloxamer 188. ANNs and mixture experimental design can be used as powerful data modeling tools in the systematic development of SDs. Taking into account advantages and disadvantages of both techniques, their combined application should be encouraged.

Source:
Drug Development and Industrial Pharmacy, 2016, 42, 3, 389-402
Publisher:
  • Taylor & Francis Ltd, Abingdon
Projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)
  • Federal Republic of Germany

DOI: 10.3109/03639045.2015.1054831

ISSN: 0363-9045

PubMed: 26065534

WoS: 000369854600005

Scopus: 2-s2.0-84964228106
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2568
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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