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Chemical Composition and Bioactivity of the Essential Oils of Heracleum pyrenaicum subsp. pollinianum and Heracleum orphanidis
dc.creator | Ušjak, Ljuboš | |
dc.creator | Petrović, Silvana | |
dc.creator | Drobac, Milica | |
dc.creator | Soković, Marina | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Ćirić, Ana D. | |
dc.creator | Niketić, Marjan | |
dc.date.accessioned | 2019-09-02T11:51:30Z | |
dc.date.available | 2019-09-02T11:51:30Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2571 | |
dc.description.abstract | The objective of this research was to analyze the chemical composition, antimicrobial and cytotoxic activity of Heracleum pyrenaicum subsp. pollinianum (Bertol.) F. Pedrotti & Pignatti (HPP) and H. orphanidis Boiss. (HO) essential oils. The composition of the oils was analyzed by GC and GC-MS. β-Pinene (35.1%) was the most abundant compound in HPP root oil, while (Z)-falcarinol (80.0%) dominated in HO root oil. (E)-Nerolidol (28.5%) was the main constituent in HPP leaf oil. HPP fruit oil, as well as HO leaf and fruit oils mainly contained aliphatic esters, mostly octyl acetate (50.5-84.5%). Antimicrobial screening was performed by microdilution method against eight bacterial and eight fungal strains. The strongest antibacterial activity was shown by both root oils (MICs 0.02-0.60 mg/mL and MBCs 0.04-2.50 mg/mL for HPP, and MICs 0.02-1.25 mg/mL and MBCs 0.04-2.50 mg/mL for HO), while the best antifungal potential was exhibited by HPP fruit oil (MICs 0.30-0.60 mg/mL and MFCs 0.60-1.25 mg/mL) and HO leaf oil (MICs 0.15-0.63 mg/mL and MFCs 0.30-1.25 mg/mL). The tested root and fruit oils exhibited strong cytotoxic effect, which was determined by MTT test against HeLa (IC50 7.53-21.07 μg/mL) and LS174 (IC50 24.16-58.86 μg/mL) cell lines. | en |
dc.publisher | Natural Products Inc, Westerville | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Natural Product Communications | |
dc.subject | Antimicrobial activity | en |
dc.subject | Chemical composition | en |
dc.subject | Cytotoxic effect | en |
dc.subject | Essential oils | en |
dc.subject | Heracleum orphanidis | en |
dc.subject | Heracleum pyrenaicum subsp. pollinianum | en |
dc.title | Chemical Composition and Bioactivity of the Essential Oils of Heracleum pyrenaicum subsp. pollinianum and Heracleum orphanidis | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Соковић, Марина; Петровић, Силвана; Никетић, Марјан; Станојковић, Татјана; Дробац, Милица; Ушјак, Љубош; Ћирић, Aна Д.; | |
dc.citation.volume | 11 | |
dc.citation.issue | 4 | |
dc.citation.spage | 529 | |
dc.citation.epage | 534 | |
dc.citation.other | 11(4): 529-534 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000375633400028 | |
dc.identifier.pmid | 27396211 | |
dc.identifier.scopus | 2-s2.0-84989193394 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/7391/Chemical_Composition_and_pub_2016.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_2990 | |
dc.type.version | publishedVersion |