Show simple item record

dc.creatorSrdić-Rajić, Tatjana
dc.creatorNikolić, Katarina
dc.creatorCavić, Milena
dc.creatorĐokić, Ivana
dc.creatorGemović, Branislava
dc.creatorPerović, Vladimir
dc.creatorVeljković, Nevena
dc.date.accessioned2019-09-02T11:51:43Z
dc.date.available2019-09-02T11:51:43Z
dc.date.issued2016
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2578
dc.description.abstractImidazoline I1 receptor signaling is associated with pathways that regulate cell viability leading to varied cell-type specific phenotypes. We demonstrated that the antihypertensive drug rilmenidine, a selective imidazoline I1 receptor agonist, modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells. Rilmenidine acts through a mechanism which involves deactivation of Ras/MAP kinases ERK, p38 and JNK. Moreover, rilmenidine renders K562 cells, which are particularly resistant to chemotherapeutic agents, susceptible to the DNA damaging drug doxorubicin. The rilmenidine co-treatment with doxorubicin reverses G2/M arrest and triggers apoptotic response to DNA damage. Our data offer new insights into the pathways associated with imidazoline I1 receptor activation in K562 cells suggesting rilmenidine as a valuable tool to deepen our understanding of imidazoline I1 receptor signaling in hematologic malignancies and to search for medicinally active agents.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.titleRilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cellsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦавић, Милена; Гемовић, Бранислава; Срдић-Рајић, Татјана; Перовић, Владимир; Вељковић, Невена; Ђокић, Ивана; Николић, Катарина;
dc.citation.volume81
dc.citation.spage172
dc.citation.epage180
dc.citation.other81: 172-180
dc.citation.rankM21
dc.identifier.wos000367787700021
dc.identifier.doi10.1016/j.ejps.2015.10.017
dc.identifier.pmid26598394
dc.identifier.scopus2-s2.0-84946239745
dc.identifier.rcubconv_3463
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record