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Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies

Authorized Users Only
2016
Authors
Simić, Milena
Paunović, Nikola
Borić, Ivan
Ranđelović, Jelena
Vojnović, Sandra
Nikodinović-Runić, Jasmina
Pekmezović, Marina
Savić, Vladimir
Article (Published version)
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Abstract
A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
Source:
Bioorganic & Medicinal Chemistry Letters, 2016, 26, 1, 235-239
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Projects:
  • Computational design, synthesis and biological evaluation of new heterocyclic compounds as selective tumorogenesis inhibitors (RS-172009)

DOI: 10.1016/j.bmcl.2015.08.086

ISSN: 0960-894X

PubMed: 26586600

WoS: 000366161600044

Scopus: 2-s2.0-84949570559
[ Google Scholar ]
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11
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2580
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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