Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies
Authorized Users Only
2016
Authors
Simić, Milena
Paunović, Nikola
Borić, Ivan
Ranđelović, Jelena
Vojnović, Sandra

Nikodinović-Runić, Jasmina

Pekmezović, Marina
Savić, Vladimir

Article (Published version)

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Show full item recordAbstract
A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
Source:
Bioorganic & Medicinal Chemistry Letters, 2016, 26, 1, 235-239Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Projects:
DOI: 10.1016/j.bmcl.2015.08.086
ISSN: 0960-894X
PubMed: 26586600