Show simple item record

dc.creatorSimić, Milena
dc.creatorPaunović, Nikola
dc.creatorBorić, Ivan
dc.creatorRanđelović, Jelena
dc.creatorVojnović, Sandra
dc.creatorNikodinović-Runić, Jasmina
dc.creatorPekmezović, Marina
dc.creatorSavić, Vladimir
dc.date.accessioned2019-09-02T11:51:45Z
dc.date.available2019-09-02T11:51:45Z
dc.date.issued2016
dc.identifier.issn0960-894X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2580
dc.description.abstractA series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172009/RS//
dc.rightsrestrictedAccess
dc.sourceBioorganic & Medicinal Chemistry Letters
dc.titleFunctionalised isocoumarins as antifungal compounds: Synthesis and biological studiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНикодиновић-Рунић, Јасмина; Ранђеловић, Јелена; Пекмезовић, Марина; Војновић, Сандра; Савић, Владимир; Симић, Милена; Борић, Иван; Пауновић, Никола;
dc.citation.volume26
dc.citation.issue1
dc.citation.spage235
dc.citation.epage239
dc.citation.other26(1): 235-239
dc.citation.rankM22
dc.identifier.wos000366161600044
dc.identifier.doi10.1016/j.bmcl.2015.08.086
dc.identifier.pmid26586600
dc.identifier.scopus2-s2.0-84949570559
dc.identifier.rcubconv_3441
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record