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dc.creatorCirković, Ivana
dc.creatorBožić, Dragana
dc.creatorDraganić, Veselin
dc.creatorLozo, Jelena
dc.creatorBerić, Tanja
dc.creatorKojić, Milan
dc.creatorArsić, Biljana
dc.creatorGaralejić, Eliana
dc.creatorĐukić, Slobodanka
dc.creatorStanković, Slavisa
dc.date.accessioned2019-09-02T11:51:51Z
dc.date.available2019-09-02T11:51:51Z
dc.date.issued2016
dc.identifier.issn1932-6203
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2583
dc.description.abstractBackground Coagulase negative staphylococci (CoNS) and Listeria monocytogenes have important roles in pathogenesis of various genital tract infections and fatal foetomaternal infections, respectively. The aim of our study was to investigate the inhibitory effects of two novel bacteriocins on biofilms of CoNS and L. monocytogenes genital isolates. Methods The effects of licheniocin 50.2 from Bacillus licheniformis VPS50.2 and crude extract of bacteriocins produced by Lactococcus lactis subsp. lactis biovar. diacetylactis BGBU1-4 (BGBU1-4 crude extract) were evaluated on biofilm formation and formed biofilms of eight CoNS (four S. epidermidis, two S. hominis, one S. lugdunensis and one S. haemolyticus) and 12 L. monocytogenes genital isolates. Results Licheniocin 50.2 and BGBU1-4 crude extract inhibited the growth of both CoNS and L. monocytogenes isolates, with MIC values in the range between 200-400 AU/ml for licheniocin 50.2 and 400-3200 AU/ml for BGBU1-4 crude extract. Subinhibitory concentrations (1/2 x and 1/4 x MIC) of licheniocin 50.2 inhibited biofilm formation by all CoNS isolates (p lt 0.05, respectively), while BGBU1-4 crude extract inhibited biofilm formation by all L. monocytogenes isolates (p lt 0.01 and p lt 0.05, respectively). Both bacteriocins in concentrations of 100 AU/mL and 200 AU/mL reduced the amount of 24 h old CoNS and L. monocytogenes biofilms (p lt 0.05, p lt 0.01, p lt 0.001). Conclusions This study suggests that novel bacteriocins have potential to be used for genital application, to prevent biofilm formation and/or to eradicate formed biofilms, and consequently reduce genital and neonatal infections by CoNS and L. monocytogenes.en
dc.publisherPublic Library Science, San Francisco
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175039/RS//
dc.rightsopenAccess
dc.sourcePLoS One
dc.titleLicheniocin 50.2 and Bacteriocins from Lactococcus lactis subsp lactis biovar. diacetylactis BGBU1-4 Inhibit Biofilms of Coagulase Negative Staphylococci and Listeria monocytogenes Clinical Isolatesen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractДраганић, Веселин; Божић, Драгана; Ђукић, Слободанка; Станковић, Слависа; Којић, Милан; Лозо, Јелена; Цирковић, Ивана; Берић, Тања; Aрсић, Биљана; Гаралејић, Елиана;
dc.citation.volume11
dc.citation.issue12
dc.citation.other11(12): -
dc.citation.rankM21
dc.identifier.wos000389580900068
dc.identifier.doi10.1371/journal.pone.0167995
dc.identifier.pmid27930711
dc.identifier.scopus2-s2.0-85002824950
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1260/2581.pdf
dc.identifier.rcubconv_3382
dc.type.versionpublishedVersion


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