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dc.creatorPirković, Andrea
dc.creatorŽivković, Lada
dc.creatorBorozan, Sunčica
dc.creatorZlatković-Svenda, Mirjana
dc.creatorDekanski, Dragana
dc.creatorJančić, Ivan
dc.creatorRadak-Perović, Marija
dc.creatorBajić, Vladan
dc.creatorPotparević, Biljana
dc.date.accessioned2019-09-02T11:51:52Z
dc.date.available2019-09-02T11:51:52Z
dc.date.issued2016
dc.identifier.issn0951-418X
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2584
dc.description.abstractThe effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyrighten
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourcePhytotherapy Research
dc.titleDry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПирковић, Aндреа; Живковић, Лада; Потпаревић, Биљана; Борозан, Сунчица; Радак-Перовић, Марија; Бајић, Владан; Декански, Драгана; Јанчић, Иван; Златковић-Свенда, Мирјана;
dc.citation.volume30
dc.citation.issue10
dc.citation.spage1615
dc.citation.epage1623
dc.citation.other30(10): 1615-1623
dc.citation.rankM22
dc.identifier.wos000385700400007
dc.identifier.doi10.1002/ptr.5662
dc.identifier.pmid27271301
dc.identifier.scopus2-s2.0-84973563650
dc.identifier.rcubconv_3381
dc.type.versionpublishedVersion


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