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Usnea barbata CO2-supercritical extract in alkyl polyglucoside-based emulsion system: contribution of Confocal Raman imaging to the formulation development of a natural product

Authorized Users Only
2016
Authors
Žugić, Ana R.
Lunter, Dominique
Daniels, Rolf
Pantelić, Ivana
Tasić-Kostov, Marija
Tadić, Vanja M.
Mišić, Dušan
Arsić, Ivana A.
Savić, Snežana
Article (Published version)
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Abstract
Topical treatment of skin infections is often limited by drawbacks related to both antimicrobial agents and their vehicles. In addition, considering the growing promotion of natural therapeutic products, our objective was to develop and evaluate naturally-based emulsion system, as prospective topical formulation for skin infections-treatment. Therefore, alkyl polyglucoside surfactants were used for stabilization of a vehicle serving as potential carrier for supercritical CO2-extract of Usnea barbata, lichen with well-documented antimicrobial activity, incorporated using two protocols and three concentrations. Comprehensive physicochemical characterization suggested possible involvement of extract's particles in stabilization of the investigated system. Raman spectral imaging served as the key method in disclosing extract's particles potential to participate in the microstructure of the tested emulsion system via three mechanisms: (1) particle-particle aggregation, (2) adsorption at the... oil-water interface and (3) hydrophobic particle-surfactant interactions. Stated extract-vehicle interaction proved to be correlated to the preparation procedure and extract concentration on one hand and to affect the physicochemical and biopharmaceutical features of investigated system, on the other hand. Thereafter, formulation with the best preliminary stability and liberation profile was selected for further efficiency and in vivo skin irritation potential evaluation, implying pertinent in vitro antimicrobial activity against G+ bacteria and overall satisfying preliminary safety profile.

Source:
Pharmaceutical Development and Technology, 2016, 21, 5, 563-575
Publisher:
  • Taylor & Francis Ltd, Abingdon
Projects:
  • Functional physiologically active plant materials with additional values for application in pharmaceutical and food industry (RS-45017)
  • Development of micro- and nanosystems as carriers for drugs with anti-inflammatory effect and methods for their characterization (RS-34031)
  • German Academic Exchange Service (DAAD) A/11/84475

DOI: 10.3109/10837450.2015.1026606

ISSN: 1083-7450

PubMed: 26135231

WoS: 000375462900006

Scopus: 2-s2.0-84969244162
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2588
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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