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dc.creatorIvanišević, Jasmina
dc.creatorKotur-Stevuljević, Jelena
dc.creatorStefanović, Aleksandra
dc.creatorSpasić, Slavica
dc.creatorVučinić-Mihailović, Violeta
dc.creatorVidenović-Ivanov, Jelica
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:52:10Z
dc.date.available2019-09-02T11:52:10Z
dc.date.issued2016
dc.identifier.issn0014-2972
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2594
dc.description.abstractBackground It has been reported that high-density lipoprotein (HDL) particles have anti-inflammatory and antioxidant roles thanks to different enzymes such as paraoxonase 1 (PON1). Under inflammatory and oxidative stress conditions, HDL particles may lose their protective properties. Sarcoidosis is an inflammatory disease characterized by excessive oxidative stress. Serum amyloid A (SAA) is produced in liver and in granulomas, and its concentration increases in inflammatory conditions contributing to increased catabolism of HDL particles. The aim of our study was to determine PON1 activity, SAA concentration and their associations in patients with sarcoidosis. Materials and methods Inflammatory [high-sensitive C-reactive protein (hsCRP), angiotensin-converting enzyme (ACE), SAA], lipid [total cholesterol (TC), HDL-cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG)] oxidative stress status parameters [total oxidant status (TOS), malondialdehyde (MDA), pro-oxidant-antioxidant balance (PAB), sulfhydryl (SH) groups] and PON1 activities were determined in serum of 72 patients with sarcoidosis and 62 healthy subjects. Results HsCRP (P lt 0.05), TC, LDL-c, TG, SAA, TOS, MDA and PAB (P lt 0.001) were significantly higher, whereas HDL-c, SH groups and PON1 activity (P lt 0.001) were significantly lower in patients with sarcoidosis when compared with controls. PON1 showed significant association with SAA, MDA and PAB. It was shown that 71% of decrease in PON1 activity may be explained by increase in TOS, PAB and SAA concentration. Conclusions We found decreased PON1 activity and increased SAA concentration in patients with sarcoidosis. Inflammatory condition presented by high SAA was implicated in impaired HDL functionality evident through dysregulated PON1 activity. Excessive oxidative stress was also involved in dysregulation of PON1 activity.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Clinical Investigation
dc.titleAssociation of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Стефановић, Aлександра; Спасић, Славица; Вучинић-Михаиловић, Виолета; Виденовић-Иванов, Јелица; Иванишевић, Јасмина; Котур-Стевуљевић, Јелена;
dc.citation.volume46
dc.citation.issue5
dc.citation.spage418
dc.citation.epage424
dc.citation.other46(5): 418-424
dc.citation.rankM21
dc.identifier.wos000374651600006
dc.identifier.doi10.1111/eci.12610
dc.identifier.pmid26919159
dc.identifier.scopus2-s2.0-84960894929
dc.identifier.rcubconv_3545
dc.type.versionpublishedVersion


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