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Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults

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2016
Authors
Topić, Aleksandra
Malić, Živka
Francuski, Đorđe
Stanković, Marija
Marković, Bojan
Soskić, Blagoje
Tomić, Branko
Ilić, Stefan
Dobrivojević, Snežana
Drca, Sanja
Radojković, Dragica
Article (Published version)
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Abstract
Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI lt 25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases.
Source:
Biomarkers, 2016, 21, 2, 186-193
Publisher:
  • Taylor & Francis Ltd, Abingdon
Projects:
  • Complex diseases as a model system for phenotype modulation- structural and functional analysis of molecular biomarkers (RS-173008)

DOI: 10.3109/1354750X.2015.1126647

ISSN: 1354-750X

PubMed: 26754535

WoS: 000373230900014

Scopus: 2-s2.0-84954304812
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2600
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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