Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults
Authorized Users Only
2016
Authors
Topić, Aleksandra
Malić, Živka
Francuski, Đorđe
Stanković, Marija
Marković, Bojan

Soskić, Blagoje
Tomić, Branko
Ilić, Stefan
Dobrivojević, Snežana
Drca, Sanja
Radojković, Dragica
Article (Published version)

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Show full item recordAbstract
Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI lt 25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases.
Source:
Biomarkers, 2016, 21, 2, 186-193Publisher:
- Taylor & Francis Ltd, Abingdon
Projects:
DOI: 10.3109/1354750X.2015.1126647
ISSN: 1354-750X
PubMed: 26754535