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dc.creatorKovacević, Jovana
dc.creatorMladenović, Aleksandar
dc.creatorĐuriš, Jelena
dc.creatorIbrić, Svetlana
dc.date.accessioned2019-09-02T11:52:20Z
dc.date.available2019-09-02T11:52:20Z
dc.date.issued2016
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2602
dc.description.abstractGastro-resistant pellets were prepared by use of three different drug loading techniques (powder layering, solution layering and suspension layering) and two different enteric coating techniques (powder layering and suspension layering). Pellets produced by different layering techniques were compared in terms of morphological characteristics, content of drug, release properties and stability. Drug loaded pellets produced by the use of powder layering had much more pronounced surface roughness in comparison to other tested techniques. Higher weight gains of enteric polymer were needed to achieve the same level of gastric resistance when powder layering was employed to apply enteric layer than when it was applied by suspension layering. Both tested techniques of enteric coating application enabled complete dissolution of drug in buffer stage of dissolution test. Suspension layering proved to be superior to other techniques both in drug loading and enteric layering phase.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.titleEvaluation of powder, solution and suspension layering for the preparation of enteric coated pelletsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКовацевић, Јована; Ђуриш, Јелена; Младеновић, Aлександар; Ибрић, Светлана;
dc.citation.volume85
dc.citation.spage84
dc.citation.epage93
dc.citation.other85: 84-93
dc.citation.rankM21
dc.identifier.wos000371996000010
dc.identifier.doi10.1016/j.ejps.2016.01.018
dc.identifier.pmid26796145
dc.identifier.scopus2-s2.0-84961613458
dc.identifier.rcubconv_3515
dc.type.versionpublishedVersion


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