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Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity

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2016
2603.pdf (2.102Mb)
Authors
Vidović, Bojana
Milašinović, Nikola
Kotur-Stevuljević, Jelena
Dilber, Sanda
Kalagasidis-Krusić, Melina T.
Đorđević, Brižita
Knežević-Jugović, Zorica
Article (Published version)
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Abstract
Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through ...its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid.

Source:
Hemijska industrija, 2016, 70, 1, 49-58
Publisher:
  • Savez hemijskih inženjera, Beograd
Projects:
  • Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)

DOI: 10.2298/HEMIND141119010V

ISSN: 0367-598X

WoS: 000372733800006

Scopus: 2-s2.0-84960341974
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2605
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Pharmacy

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