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Synthesis, cytotoxicity and computational study of novel protoberberine derivatives

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2016
2604.pdf (2.380Mb)
Authors
Simić, Milena
Damjanović, Ana B.
Kalinić, Marko
Tasić, Gordana
Erić, Slavica
Antić-Stanković, Jelena
Savić, Vladimir
Article (Published version)
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Abstract
A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds.
Source:
Journal of the Serbian Chemical Society, 2016, 81, 2, 103-123
Publisher:
  • Srpsko hemijsko društvo, Beograd
Projects:
  • Computational design, synthesis and biological evaluation of new heterocyclic compounds as selective tumorogenesis inhibitors (RS-172009)

DOI: 10.2298/JSC150525090S

ISSN: 0352-5139

WoS: 000372079900001

Scopus: 2-s2.0-84963616111
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2606
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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