Synthesis, cytotoxicity and computational study of novel protoberberine derivatives

2016
Authors
Simić, Milena
Damjanović, Ana B.

Kalinić, Marko

Tasić, Gordana

Erić, Slavica
Antić-Stanković, Jelena

Savić, Vladimir

Article (Published version)
Metadata
Show full item recordAbstract
A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds.
Source:
Journal of the Serbian Chemical Society, 2016, 81, 2, 103-123Publisher:
- Srpsko hemijsko društvo, Beograd
Projects:
DOI: 10.2298/JSC150525090S
ISSN: 0352-5139