Synthesis, cytotoxicity and computational study of novel protoberberine derivatives
Damjanović, Ana B.
Article (Published version)
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A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds.
Source:Journal of the Serbian Chemical Society, 2016, 81, 2, 103-123
- Srpsko hemijsko društvo, Beograd