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Synthesis, cytotoxicity and computational study of novel protoberberine derivatives
dc.creator | Simić, Milena | |
dc.creator | Damjanović, Ana B. | |
dc.creator | Kalinić, Marko | |
dc.creator | Tasić, Gordana | |
dc.creator | Erić, Slavica | |
dc.creator | Antić-Stanković, Jelena | |
dc.creator | Savić, Vladimir | |
dc.date.accessioned | 2019-09-02T11:52:26Z | |
dc.date.available | 2019-09-02T11:52:26Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2606 | |
dc.description.abstract | A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds. | en |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172009/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.title | Synthesis, cytotoxicity and computational study of novel protoberberine derivatives | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Aнтић-Станковић, Јелена; Калинић, Марко; Дамјановић, Aна Б.; Тасић, Гордана; Ерић, Славица; Симић, Милена; Савић, Владимир; | |
dc.citation.volume | 81 | |
dc.citation.issue | 2 | |
dc.citation.spage | 103 | |
dc.citation.epage | 123 | |
dc.citation.other | 81(2): 103-123 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000372079900001 | |
dc.identifier.doi | 10.2298/JSC150525090S | |
dc.identifier.scopus | 2-s2.0-84963616111 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1285/2604.pdf | |
dc.type.version | publishedVersion |