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dc.creatorPopović, Dejana
dc.creatorDamjanović, Svetozar S.
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorPešić, Vesna
dc.creatorStojiljković, Stanimir
dc.creatorBanović, Marko
dc.creatorRistić, Arsen
dc.creatorMantegazza, Valentina
dc.creatorAgostoni, Piergiuseppe
dc.date.accessioned2019-09-02T11:52:48Z
dc.date.available2019-09-02T11:52:48Z
dc.date.issued2016
dc.identifier.issn1558-2027
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2619
dc.description.abstractThe usage of alcohol is widespread, but the effects of acute alcohol ingestion on exercise performance and the stress hormone axis are not fully elucidated.We studied 10 healthy white men, nonhabitual drinkers, by Doppler echocardiography at rest, spirometry, and maximal cardiopulmonary exercise test (CPET) in two visits (2-4 days in between), one after administration of 1.5g/kg ethanol (whisky) diluted at 15% in water, and the other after administration of an equivalent volume of water. Plasma levels of NT-pro-BNP, cortisol, and adrenocorticotropic hormone (ACTH) were also measured 10min before the test, at maximal effort and at the third minute of recovery. Ethanol concentration was measured from resting blood samples by gas chromatography and it increased from 0.00 +/- 0.00 to 1.25 +/- 0.54 parts per thousand (P lt 0.001). Basal echocardiographic and spirometric parameters were normal and remained so after acute alcohol intake, whereas ACTH, cortisol, and NT-pro-BNP nonsignificantly increased in all phases of the test. CPET data suggested a trend toward a slight reduction of exercise performance (peak VO2=3008 +/- 638 vs. 2900 +/- 543ml/min, ns; peak workload=269 +/- 53 vs. 249 +/- 40W, ns; test duration 13.7 +/- 2.2 vs. 13.3 +/- 1.7min, ns; VE/VCO2 22.1 +/- 1.4 vs. 23.3 +/- 2.9, ns). Ventilatory equivalent for carbon dioxide at rest was higher after alcohol intake (28 +/- 2.5 vs. 30.4 +/- 3.2, P=0.039) and maximal respiratory exchange ratio was lower after alcohol intake (1.17 +/- 0.02 vs. 1.14 +/- 0.04, P=0.04). In conclusion, we showed that acute alcohol intake in healthy white men is associated with a nonsignificant exercise performance reduction and stress hormone stimulation, with an unchanged exercise metabolism.en
dc.publisherLippincott Williams & Wilkins, Philadelphia
dc.relationFaculty of Pharmacy University of Belgrade
dc.rightsrestrictedAccess
dc.sourceJournal of Cardiovascular Medicine
dc.titleExercise capacity is not impaired after acute alcohol ingestion: a pilot studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДамјановић, Светозар С.; Aгостони, Пиергиусеппе; Ристић, Aрсен; Бановић, Марко; Стојиљковић, Станимир; Плећаш-Соларовић, Босиљка; Мантегазза, Валентина; Пешић, Весна; Поповић, Дејана;
dc.citation.volume17
dc.citation.issue12
dc.citation.spage896
dc.citation.epage901
dc.citation.other17(12): 896-901
dc.citation.rankM23
dc.identifier.wos000387271400009
dc.identifier.doi10.2459/JCM.0000000000000151
dc.identifier.pmid25083719
dc.identifier.scopus2-s2.0-84905299128
dc.type.versionpublishedVersion


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