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dc.creatorBecarević, Mirjana
dc.creatorMirković, Duško
dc.creatorIgnjatović, Svetlana
dc.date.accessioned2019-09-02T11:53:04Z
dc.date.available2019-09-02T11:53:04Z
dc.date.issued2016
dc.identifier.issn0770-3198
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2629
dc.description.abstractAlthough numerous studies investigated the association between homocysteine (Hcy), tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP) and apolipoproteins (apo(s)) with thrombosis and/or recurrent pregnancy losses, studies that analyzed the abovementioned parameters and multiple positivity of antiphospholipid antibodies (aPL Abs) in patients with primary antiphospholipid syndrome (PAPS) are lacking. Therefore, the aim of this study was to analyze the presence of various combinations of the abovementioned parameters and their associations with clinical and/or serological features of PAPS. High-pressure liquid chromatography (HPLC) was used for determination of Hcy, while apoAI, apoB, and lipoprotein (Lp) (a) concentrations were estimated by immunonephelometry. High-sensitivity C-reactive protein (hsCRP) was measured by immunoturbidimetry. Apo (a), TNF-alpha, and aPL Abs were measured by ELISA. Various combinations of analyzed parameters (Hcy/CRP/TNF/apoAI/apoB/apo (a)/Lp (a)) were not associated with a single presence of either aPL Abs. Double positivity for both isotypes of anticardiolipin (aCL) Abs (IgG + IgM) was associated with the increased apoB levels. The presence of the IgG isotype of both aCL + anti-beta2 glycoprotein I (a beta 2gpI) Abs was associated with the highest number of analyzed parameters (i.e., increased levels of hsCRP, Lp (a), and apo (a)). The presence of the IgG isotype of both aCL + a beta 2gpI Abs was associated with the highest number of vascular impairment parameters in patients with PAPS, and this combination confers the highest risk for the recurrence of thrombotic episodes. This is the first report that analyzed the association between various combinations of vascular impairment parameters with multiple aPL Ab positivity. Our results provide a rationale for further investigations of therapeutic approaches for PAPS patients.en
dc.publisherSpringer London Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Rheumatology
dc.titleDouble positivity of the IgG isotype of both anticardiolipin and anti-beta 2gpI antibodies is associated with the highest number of vascular impairment parameters in patients with primary antiphospholipid syndrome: preliminary dataen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИгњатовић, Светлана; Бецаревић, Мирјана; Мирковић, Душко;
dc.citation.volume35
dc.citation.issue12
dc.citation.spage2947
dc.citation.epage2954
dc.citation.other35(12): 2947-2954
dc.citation.rankM23
dc.identifier.wos000388826200011
dc.identifier.doi10.1007/s10067-016-3438-z
dc.identifier.pmid27743141
dc.identifier.scopus2-s2.0-84991080565
dc.identifier.rcubconv_3717
dc.type.versionpublishedVersion


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