Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications

2016
Authors
Krnjeta, TijanaMirković, Ljiljana
Ignjatović, Svetlana

Tomasević, Dragana
Lukić, Jelena
Topalov, Drina
Soldatović, Ivan
Majkić-Singh, Nada
Article (Published version)

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Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0....04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.
Source:
Journal of Medical Biochemistry, 2016, 35, 3, 312-318Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.1515/jomb-2016-0013
ISSN: 1452-8258
PubMed: 28356882