Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications

2016
Authors
Krnjeta, TijanaMirković, Ljiljana
Ignjatović, Svetlana

Tomasević, Dragana
Lukić, Jelena
Topalov, Drina
Soldatović, Ivan
Majkić-Singh, Nada
Article (Published version)

Metadata
Show full item recordAbstract
Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0....04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.
Source:
Journal of Medical Biochemistry, 2016, 35, 3, 312-318Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
- Biomarkers of organ damage and dysfunction (RS-175036)
DOI: 10.1515/jomb-2016-0013
ISSN: 1452-8258
PubMed: 28356882
WoS: 000379520000005
Scopus: 2-s2.0-84978818624
Collections
Institution/Community
PharmacyTY - JOUR AU - Krnjeta, Tijana AU - Mirković, Ljiljana AU - Ignjatović, Svetlana AU - Tomasević, Dragana AU - Lukić, Jelena AU - Topalov, Drina AU - Soldatović, Ivan AU - Majkić-Singh, Nada PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2638 AB - Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications VL - 35 IS - 3 SP - 312 EP - 318 DO - 10.1515/jomb-2016-0013 ER -
@article{ author = "Krnjeta, Tijana and Mirković, Ljiljana and Ignjatović, Svetlana and Tomasević, Dragana and Lukić, Jelena and Topalov, Drina and Soldatović, Ivan and Majkić-Singh, Nada", year = "2016", abstract = "Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications", volume = "35", number = "3", pages = "312-318", doi = "10.1515/jomb-2016-0013" }
Krnjeta, T., Mirković, L., Ignjatović, S., Tomasević, D., Lukić, J., Topalov, D., Soldatović, I.,& Majkić-Singh, N.. (2016). Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(3), 312-318. https://doi.org/10.1515/jomb-2016-0013
Krnjeta T, Mirković L, Ignjatović S, Tomasević D, Lukić J, Topalov D, Soldatović I, Majkić-Singh N. Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications. in Journal of Medical Biochemistry. 2016;35(3):312-318. doi:10.1515/jomb-2016-0013 .
Krnjeta, Tijana, Mirković, Ljiljana, Ignjatović, Svetlana, Tomasević, Dragana, Lukić, Jelena, Topalov, Drina, Soldatović, Ivan, Majkić-Singh, Nada, "Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications" in Journal of Medical Biochemistry, 35, no. 3 (2016):312-318, https://doi.org/10.1515/jomb-2016-0013 . .