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Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications
dc.creator | Krnjeta, Tijana | |
dc.creator | Mirković, Ljiljana | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Tomasević, Dragana | |
dc.creator | Lukić, Jelena | |
dc.creator | Topalov, Drina | |
dc.creator | Soldatović, Ivan | |
dc.creator | Majkić-Singh, Nada | |
dc.date.accessioned | 2019-09-02T11:53:21Z | |
dc.date.available | 2019-09-02T11:53:21Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1452-8258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2638 | |
dc.description.abstract | Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE. Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis. Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p>0.05). The highest difference ob served was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95% CI=0.092-0.7836) and PE complications including severe early-onset PE (OR=0.304; 95% CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95% CI=0.081-0.874). Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications. | en |
dc.publisher | Društvo medicinskih biohemičara Srbije, Beograd i Versita | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Medical Biochemistry | |
dc.title | Protective role of maternal P.VAL158MET catechol-o-methyltransferase polymorphism against early-onset preeclampsia and its complications | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Солдатовић, Иван; Томасевић, Драгана; Игњатовић, Светлана; Лукић, Јелена; Мајкић-Сингх, Нада; Топалов, Дрина; Мирковић, Љиљана; Крњета, Тијана; | |
dc.citation.volume | 35 | |
dc.citation.issue | 3 | |
dc.citation.spage | 312 | |
dc.citation.epage | 318 | |
dc.citation.other | 35(3): 312-318 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000379520000005 | |
dc.identifier.doi | 10.1515/jomb-2016-0013 | |
dc.identifier.pmid | 28356882 | |
dc.identifier.scopus | 2-s2.0-84978818624 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1314/2636.pdf | |
dc.type.version | publishedVersion |