Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex
Samo za registrovane korisnike
2016
Autori
Mancić, BojanaStevanović, Ivana
Ilić, Tihomir V.
Đurić, Ana
Stojanović, Ivana
Milanović, Slađan
Ninković, Milica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, co...mpared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.
Izvor:
Neurochemistry International, 2016, 100, 120-127Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- Ministry of Defense of the Republic of Serbia (Project no. MFVMA/6/15-17)
DOI: 10.1016/j.neuint.2016.09.009
ISSN: 0197-0186
PubMed: 27623095
WoS: 000388780300014
Scopus: 2-s2.0-84988526941
Institucija/grupa
PharmacyTY - JOUR AU - Mancić, Bojana AU - Stevanović, Ivana AU - Ilić, Tihomir V. AU - Đurić, Ana AU - Stojanović, Ivana AU - Milanović, Slađan AU - Ninković, Milica PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2639 AB - Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, compared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Neurochemistry International T1 - Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex VL - 100 SP - 120 EP - 127 DO - 10.1016/j.neuint.2016.09.009 ER -
@article{ author = "Mancić, Bojana and Stevanović, Ivana and Ilić, Tihomir V. and Đurić, Ana and Stojanović, Ivana and Milanović, Slađan and Ninković, Milica", year = "2016", abstract = "Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in activity of excitatory and inhibitory systems as well as redox homeostasis. Our aim was to investigate the effect of single (SS) and repeated session (RS) of intermittentand continuous theta-burst stimulation (iTBS; cTBS) on the expression of vesicular and plasmatic glutamate transporters 1 (vGluT1 and GLT-1), glial fibrillary acidic protein (GFAP) and influence on oxidative status in rats cerebellar tissue and plasma. Redox state parameters in cerebellar tissue and plasma were assessed 24 h after single and 48 h after the last TBS session. Molecular changes were examined by immunofluorescence. Stimulation significantly increased thiol groups (SH) in tissue of SS iTBS group, and decreased in iTBS RS. Activity of glucose-6-phosphate-dehydrogenase (G6PD) was increased markedly in cTBS RS. Immunoreactivity of vGluT1 in cTBS RS decreased, while GLT-1 increased in cTBS SS and cTBS RS, compared to control. Present study gives insight in molecular and biochemical mechanisms by which iTBS and cTBS exerts its effects on rats cerebellar cortex.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Neurochemistry International", title = "Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex", volume = "100", pages = "120-127", doi = "10.1016/j.neuint.2016.09.009" }
Mancić, B., Stevanović, I., Ilić, T. V., Đurić, A., Stojanović, I., Milanović, S.,& Ninković, M.. (2016). Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. in Neurochemistry International Pergamon-Elsevier Science Ltd, Oxford., 100, 120-127. https://doi.org/10.1016/j.neuint.2016.09.009
Mancić B, Stevanović I, Ilić TV, Đurić A, Stojanović I, Milanović S, Ninković M. Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex. in Neurochemistry International. 2016;100:120-127. doi:10.1016/j.neuint.2016.09.009 .
Mancić, Bojana, Stevanović, Ivana, Ilić, Tihomir V., Đurić, Ana, Stojanović, Ivana, Milanović, Slađan, Ninković, Milica, "Transcranial theta-burst stimulation alters GLT-1 and vGluT1 expression in rat cerebellar cortex" in Neurochemistry International, 100 (2016):120-127, https://doi.org/10.1016/j.neuint.2016.09.009 . .