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Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine

Spektrofotometrijsko određivanje fluokortolona u tabletama sa reagensom 1,4-dihidrazinoftalazinom

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Authors
Čudina, Olivera
Vladimirov, Sote
Živanov-Stakić, Dobrila
Agbaba, Danica
Contribution To Periodical (Published version)
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Abstract
The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results.
Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima.
Keywords:
fluocortolone / 1, 4-dihydrazinophthalazine / tablets / spectrophotometry
Source:
Journal of the Serbian Chemical Society, 2000, 65, 9, 645-648
Publisher:
  • Srpsko hemijsko društvo, Beograd

ISSN: 0352-5139

WoS: 000089106700005

Scopus: 2-s2.0-0034366827
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/264
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