The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results.
Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima.
TY - JOUR
AU - Čudina, Olivera
AU - Vladimirov, Sote
AU - Živanov-Stakić, Dobrila
AU - Agbaba, Danica
PY - 2000
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/264
AB - The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results.
AB - Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima.
PB - Srpsko hemijsko društvo, Beograd
T2 - Journal of the Serbian Chemical Society
T1 - Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine
T1 - Spektrofotometrijsko određivanje fluokortolona u tabletama sa reagensom 1,4-dihidrazinoftalazinom
VL - 65
IS - 9
SP - 645
EP - 648
UR - https://hdl.handle.net/21.15107/rcub_farfar_264
ER -
@article{
author = "Čudina, Olivera and Vladimirov, Sote and Živanov-Stakić, Dobrila and Agbaba, Danica",
year = "2000",
abstract = "The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results., Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine, Spektrofotometrijsko određivanje fluokortolona u tabletama sa reagensom 1,4-dihidrazinoftalazinom",
volume = "65",
number = "9",
pages = "645-648",
url = "https://hdl.handle.net/21.15107/rcub_farfar_264"
}
Čudina, O., Vladimirov, S., Živanov-Stakić, D.,& Agbaba, D.. (2000). Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 65(9), 645-648.
https://hdl.handle.net/21.15107/rcub_farfar_264
Čudina O, Vladimirov S, Živanov-Stakić D, Agbaba D. Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine. in Journal of the Serbian Chemical Society. 2000;65(9):645-648.
https://hdl.handle.net/21.15107/rcub_farfar_264 .
Čudina, Olivera, Vladimirov, Sote, Živanov-Stakić, Dobrila, Agbaba, Danica, "Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine" in Journal of the Serbian Chemical Society, 65, no. 9 (2000):645-648,
https://hdl.handle.net/21.15107/rcub_farfar_264 .
