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Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma

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Authors
Karlicić, Vukoica
Vuković, Jelena
Stanojević, Ivan
Sotirović, Jelena
Perić, Alexandra
Jović, Milena
Cvijanović, Vlado
Đukić, Mirjana
Banović, Tatjana
Vojvodić, Danilo
Article (Published version)
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Abstract
Purpose: Advanced lung carcinoma is charasterized with fast disease progression. Interleukin (IL)10 and transforming growth factor (TGF)b1 are immunosuppressive mediators and their role in lung carcinoma pathogenesis and in the antitumor response has not yet been elucidated. The purpose of this study was to correlate IL10 and TGFb1 levels in the serum and lung tumor microcirculation with clinical stage, disease extent, histological features and TNM stage. Methods: The study included 41 lung cancer patients in clinical stage III and IV. Histological type was determined immunohistochemically, while tumor size, localization and dissemination were determined radiologically by multislice computerized tomography (MSCT). IL10 and TGFb1 levels were quantified with commercial flow cytometric test in serum and lung tumor microcirculation samples. Results: Non small cell lung cancer (NSCLC) patients had significantly elevated TGFb1 while small cell lung cancer (SCLC) patients had significantly in...creased IL10 in tumor microcirculation. IL10 was significantly elevated in patients with the largest tumors, as well as in patients with III clinical stage and without metastases, both in the serum and tumor microcirculation. TGFb1 was significantly increased in serum and tumor microcirculation in patients with larger tumors. We found significant correlation between these two immunosuppressive cytokines, IL10 and TGFbl, in tumor microcirculation but not in patient serum samples. Conclusion: IL10 and TGFb1 in systemic and tumor microcirculation are significantly associated with particular histological type of lung cancer, tumor size and degree of disease extent.

Keywords:
ILIO / Lung cancer / TGF1 / Tumor microcirculation / Tumor size
Source:
Journal of BUON, 2016, 21, 5, 1210-1218
Publisher:
  • Balkan Union of Oncology (B.U.ON.)
Projects:
  • Preventive, therapeutic, and ethical approach in preclinical and clinical studies of the genes and modulators of redox cell signaling in immune, inflammatory and proliferative cell response (RS-41018)

ISSN: 1107-0625

PubMed: 27837625

WoS: 000388782200023

Scopus: 2-s2.0-85009423829
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2641
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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