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dc.creatorLukić, Jovanka
dc.creatorDinić, Miroslav
dc.creatorMarčetić, Mirjana
dc.creatorMilenković, Marina
dc.creatorBegović, Jelena
dc.creatorStrahinić, Ivana
dc.date.accessioned2019-09-02T11:53:30Z
dc.date.available2019-09-02T11:53:30Z
dc.date.issued2016
dc.identifier.issn0534-0012
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2645
dc.description.abstractAim of this work was to assess the metabolic and physiological changes that occurred in the hind gut of rats after feeding with soybean carbohydrates alone and in combination with Lactobacillus helveticus BGRA43. Wistar rats were gavaged with soybean flour for 28 days. The parameters assessed included fecal volatile organic compounds, and L-lactate, reducing sugars, proteins, ammonia and water levels in the colonic lumen. The presence of lactic acid (LAB), sulfate reducing (SRB) and methanogenic bacteria was assessed by semi-quantitative PCR. Malondialdehyde levels as well as lymphoid tissue size in ileal and colonic mucosa were also evaluated. On the basics of the results obtained, correlation network was created, setting the parameters tested in research in two metabolic groups: saccharolytic and proteolytic fermentation group. The principal finding of the study is a negative correlation between oral administration of BGRA43 and increase of parameters related to carbohydrate fermentation in the gut, and a positive correlation to factors related to proteolytic fermentation. On the contrary, soybean carbohydrates were correlated with increased values of factors related to carbohydrate catabolism. Different effects of BGRA43 and soybean carbohydrates on metabolic processes in colonic lumen indicate the possibility of applying the BGRA43 in alleviating the gastrointestinal symptoms occurring after consuming hardly digestible carbohydrates.en
dc.publisherDruštvo genetičara Srbije, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173019/RS//
dc.rightsopenAccess
dc.sourceGenetika, Belgrade
dc.titleEffects of soybean carbohydrates and Lactobacillus helveticus BGRA43 on metabolic processes in rat colonen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractЛукић, Јованка; Динић, Мирослав; Марчетић, Мирјана; Страхинић, Ивана; Беговић, Јелена; Миленковић, Марина;
dc.citation.volume48
dc.citation.issue3
dc.citation.spage903
dc.citation.epage921
dc.citation.other48(3): 903-921
dc.citation.rankM23
dc.identifier.wos000392920900008
dc.identifier.doi10.2298/GENSR1603903L
dc.identifier.scopus2-s2.0-85014079261
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1319/2643.pdf
dc.identifier.rcubconv_3754
dc.type.versionpublishedVersion


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