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dc.creatorKlisić, Aleksandra
dc.creatorKavarić, Nebojša
dc.creatorSoldatović, Ivan
dc.creatorBjelaković, Bojko
dc.creatorKotur-Stevuljević, Jelena
dc.date.accessioned2019-09-02T11:53:52Z
dc.date.available2019-09-02T11:53:52Z
dc.date.issued2016
dc.identifier.issn1452-8258
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2661
dc.description.abstractBackground: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.titleRelationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girlsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКотур-Стевуљевић, Јелена; Солдатовић, Иван; Каварић, Небојша; Клисић, Aлександра; Бјелаковић, Бојко;
dc.citation.volume35
dc.citation.issue3
dc.citation.spage282
dc.citation.epage292
dc.citation.other35(3): 282-292
dc.citation.rankM23
dc.identifier.wos000379520000002
dc.identifier.doi10.1515/jomb-2016-0005
dc.identifier.pmid28356879
dc.identifier.scopus2-s2.0-84978857977
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1326/2659.pdf
dc.type.versionpublishedVersion


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