Show simple item record

dc.creatorPilipović, Ivan
dc.creatorVujnović, Ivana
dc.creatorArsenović-Ranin, Nevena
dc.creatorDimitrijević, Mirjana
dc.creatorKosec, Duško
dc.creatorStojić-Vukanić, Zorica
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T11:53:58Z
dc.date.available2019-09-02T11:53:58Z
dc.date.issued2016
dc.identifier.issn0165-5728
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2664
dc.description.abstractThe study investigated the influence of peripubertal ovariectomy on the thymic noradrenaline (NA) concentration, and the thymocyte NA content and beta(2)- and alpha(1)-adrenoceptor (AR) expression in adult 2- and 11-month-old rats. In control rats, the thymic NA concentration increased with age. This increase reflected rise in the density of catecholamine (CA)-containing fluorescent nerve fibers and cells and their CA content. Additionally, the average beta(2)- and alpha(1)-AR thymocyte surface density changed in the opposite direction with age; the density of beta(2)-AR decreased, whereas that of alpha(1)-AR increased. Ovariectomy diminished the thymic NA concentration in 2-month-old rats. This reflected the decrease in the density of fluorescent nerve fibers, and CA content in fluorescent nerve fibers and non-lymphoid cells, since the thymocyte NA content was increased in ovariectomized (Ox) rats. Estrogen supplementation prevented the ovariectomy-induced changes. In Ox rats, the density of CA-synthesizing nerve fibers and non-lymphoid cells diminished with age. To the contrary, NA content in thymocytes increased with age, but it did not exceed that in 11-month-old controls. Additionally, ovariectomy diminished the average thymocyte surface density of beta(2)-ARs, but it increased that of alpha(1)-ARs in 2-month-old-rats (due to estrogen, and estrogen and progesterone deficiency, respectively). These changes, despite of the rise in circulating estrogen level post-ovariectomy, remained stable with age. This most likely reflected a decreased sensitivity to estrogen action, as a consequence of the hormone misprinting in peripubertal age. The analysis of thymocyte proliferation in culture suggested that age-and ovariectomy-induced alterations in thymocyte NA synthesis and AR expression altered NA autocrine/paracrine action on thymocytes. In conclusion, the study indicates that the ovarian hormone deficiency in peripubertal age affects ovarian steroid-dependent remodeling of thymic adrenergic regulatory network in adult rats.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Neuroimmunology
dc.titlePeripubertal ovariectomy influences thymic adrenergic network plasticity in adult ratsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПилиповић, Иван; Aрсеновић-Ранин, Невена; Лепосавић, Гордана; Вујновић, Ивана; Димитријевић, Мирјана; Косец, Душко; Стојић-Вуканић, Зорица;
dc.citation.volume297
dc.citation.spage103
dc.citation.epage116
dc.citation.other297: 103-116
dc.citation.rankM22
dc.identifier.wos000380973000014
dc.identifier.doi10.1016/j.jneuroim.2016.05.017
dc.identifier.pmid27397083
dc.identifier.scopus2-s2.0-84971268424
dc.identifier.rcubconv_3644
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record