dc.creator | Pilipović, Ivan | |
dc.creator | Vujnović, Ivana | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Dimitrijević, Mirjana | |
dc.creator | Kosec, Duško | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2019-09-02T11:53:58Z | |
dc.date.available | 2019-09-02T11:53:58Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2664 | |
dc.description.abstract | The study investigated the influence of peripubertal ovariectomy on the thymic noradrenaline (NA) concentration, and the thymocyte NA content and beta(2)- and alpha(1)-adrenoceptor (AR) expression in adult 2- and 11-month-old rats. In control rats, the thymic NA concentration increased with age. This increase reflected rise in the density of catecholamine (CA)-containing fluorescent nerve fibers and cells and their CA content. Additionally, the average beta(2)- and alpha(1)-AR thymocyte surface density changed in the opposite direction with age; the density of beta(2)-AR decreased, whereas that of alpha(1)-AR increased. Ovariectomy diminished the thymic NA concentration in 2-month-old rats. This reflected the decrease in the density of fluorescent nerve fibers, and CA content in fluorescent nerve fibers and non-lymphoid cells, since the thymocyte NA content was increased in ovariectomized (Ox) rats. Estrogen supplementation prevented the ovariectomy-induced changes. In Ox rats, the density of CA-synthesizing nerve fibers and non-lymphoid cells diminished with age. To the contrary, NA content in thymocytes increased with age, but it did not exceed that in 11-month-old controls. Additionally, ovariectomy diminished the average thymocyte surface density of beta(2)-ARs, but it increased that of alpha(1)-ARs in 2-month-old-rats (due to estrogen, and estrogen and progesterone deficiency, respectively). These changes, despite of the rise in circulating estrogen level post-ovariectomy, remained stable with age. This most likely reflected a decreased sensitivity to estrogen action, as a consequence of the hormone misprinting in peripubertal age. The analysis of thymocyte proliferation in culture suggested that age-and ovariectomy-induced alterations in thymocyte NA synthesis and AR expression altered NA autocrine/paracrine action on thymocytes. In conclusion, the study indicates that the ovarian hormone deficiency in peripubertal age affects ovarian steroid-dependent remodeling of thymic adrenergic regulatory network in adult rats. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | |
dc.title | Peripubertal ovariectomy influences thymic adrenergic network plasticity in adult rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Пилиповић, Иван; Aрсеновић-Ранин, Невена; Лепосавић, Гордана; Вујновић, Ивана; Димитријевић, Мирјана; Косец, Душко; Стојић-Вуканић, Зорица; | |
dc.citation.volume | 297 | |
dc.citation.spage | 103 | |
dc.citation.epage | 116 | |
dc.citation.other | 297: 103-116 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000380973000014 | |
dc.identifier.doi | 10.1016/j.jneuroim.2016.05.017 | |
dc.identifier.pmid | 27397083 | |
dc.identifier.scopus | 2-s2.0-84971268424 | |
dc.type.version | publishedVersion | |