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Genoprotective Capacity of Alternatively Cultivated Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Basidiocarps

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Authors
Cilerdzić, Jasmina
Stajić, Mirjana
Živković, Lada
Vukojević, Jelena
Bajić, Vladan
Potparević, Biljana
Article (Published version)
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Abstract
Ganoderma lucidum is traditionally used in Eastern medicine to preserve vitality, promote longevity, and treat disease. It possesses immunomodulatory, antitumor, antimicrobial, and antiaging activities, among others, but one of the most important is its antioxidant property, which is the basis for other effects, because free radicals trigger many diseases. The substrate commonly used for commercial cultivation of G. lucidum is not environmenwas to analyze the effect of substrate composition on the bioactivity of G. lucidum basidiocarps. G. lucidum was cultivated on 2 different substrates: (1) a mixture of wheat straw, grapevine branches, and wheat bran, and (2) wheat straw. Commercial fruiting bodies, cultivated on oak sawdust, were used as the control. 1,1- diphenyl- 2- picrylhydrazyl (DPPH) The comet test was performed to detect the degree of DNA damage in the cells that were exposed to G. lucidum extracts before and after the effect of oxidants. Higher antioxidative potential was ob...served for the extract of G. lucidum basidiocarps cultivated on wheat straw compared with that from the mixed substrate and especially with commercial ones. The alternatively cultivated basidiocarps also showed stronger antigenotoxic potential compared with commercial ones. The study showed that fruiting bodies produced on wheat straw, one of the most accessible and cheapest crop residues, are more potent antioxidant and antigenotoxic agents than commercially cultivated ones.

Source:
International Journal of Medicinal Mushrooms, 2016, 18, 12, 1061-1069
Publisher:
  • Begell House Inc, Danbury
Projects:
  • Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)

DOI: 10.1615/IntJMedMushrooms.v18.i12.10

ISSN: 1521-9437

PubMed: 28094744

WoS: 000395937300001

Scopus: 2-s2.0-85015348727
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2680
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Pharmacy

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