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dc.creatorCilerdzić, Jasmina
dc.creatorStajić, Mirjana
dc.creatorŽivković, Lada
dc.creatorVukojević, Jelena
dc.creatorBajić, Vladan
dc.creatorPotparević, Biljana
dc.date.accessioned2019-09-02T11:54:22Z
dc.date.available2019-09-02T11:54:22Z
dc.date.issued2016
dc.identifier.issn1521-9437
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2680
dc.description.abstractGanoderma lucidum is traditionally used in Eastern medicine to preserve vitality, promote longevity, and treat disease. It possesses immunomodulatory, antitumor, antimicrobial, and antiaging activities, among others, but one of the most important is its antioxidant property, which is the basis for other effects, because free radicals trigger many diseases. The substrate commonly used for commercial cultivation of G. lucidum is not environmenwas to analyze the effect of substrate composition on the bioactivity of G. lucidum basidiocarps. G. lucidum was cultivated on 2 different substrates: (1) a mixture of wheat straw, grapevine branches, and wheat bran, and (2) wheat straw. Commercial fruiting bodies, cultivated on oak sawdust, were used as the control. 1,1- diphenyl- 2- picrylhydrazyl (DPPH) The comet test was performed to detect the degree of DNA damage in the cells that were exposed to G. lucidum extracts before and after the effect of oxidants. Higher antioxidative potential was observed for the extract of G. lucidum basidiocarps cultivated on wheat straw compared with that from the mixed substrate and especially with commercial ones. The alternatively cultivated basidiocarps also showed stronger antigenotoxic potential compared with commercial ones. The study showed that fruiting bodies produced on wheat straw, one of the most accessible and cheapest crop residues, are more potent antioxidant and antigenotoxic agents than commercially cultivated ones.en
dc.publisherBegell House Inc, Danbury
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Medicinal Mushrooms
dc.titleGenoprotective Capacity of Alternatively Cultivated Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Basidiocarpsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦилердзић, Јасмина; Вукојевић, Јелена; Живковић, Лада; Потпаревић, Биљана; Стајић, Мирјана; Бајић, Владан;
dc.citation.volume18
dc.citation.issue12
dc.citation.spage1061
dc.citation.epage1069
dc.citation.other18(12): 1061-1069
dc.citation.rankM23
dc.identifier.wos000395937300001
dc.identifier.doi10.1615/IntJMedMushrooms.v18.i12.10
dc.identifier.pmid28094744
dc.identifier.scopus2-s2.0-85015348727
dc.type.versionpublishedVersion


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