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Microemulsion hydrogels - properties and current applications in drug delivery

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Authors
Đekić, Ljiljana
Martinović, Martina
Primorac, Marija
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Abstract
The current research in cutaneous and percutaneous drug delivery is focused on design of advanced carriers with enhanced applicability, stability, drug-loading capacity, and drug penetration/permeation ability. Microemulsion hydrogels (MHs) are carriers which attract the attention of a growing number of researchers who aimed to enhace dermal or transdermal delivery of drugs which are common therapeutics for different skin disorders or systemic deseases such as infections, androgenic alopecia, rheumatoid arthritis, osteoarthritis, and spondylitis, respectively. Microemulsion hydrogels is a heterogeneous group of the drug delivery systems which usually represent thermodynamically stable systems comprising dispersed oil phase within a continuous aqueous phase which is thickened with a suitable hydrophilic polymer. This chapter summarises a novel observations regarding physicochemical properties, physical and chemical stability, and drug delivery potential of this type of drug delivery sys...tems, based on comprehensive review of the research results from the relevant scientific publications. Particularly, the chapter describes the rheological behaviour of microemulsion hydrogels and elucidates the role of the most commonly used synthetic and natural hydrophilic polymers (such as carbomers, hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), xanthan gum, poloxamers) as gelling agents. Furthermore, the recently established models of the complex structure of different microemulsion hydrogels, the in vitro drug release profiles, the ex vivo permeation profiles, and the in vivo drug delivery availability of different drug molecules from the investigated systems, are described. The skin compatibility and skin irritation potential aspect of the selected hydrogel-thickened microemulsion systems is commented. The most important findings of the selected studies on microemulsion hydrogels were presented in order to illustrate their potential for achievement of topical, regional or transdermal drug delivery, including sustained drug delivery, as well as to compare to that of conventional hydrogels, microemulsions, and creams.

Keywords:
Dermal drug delivery / Ex vivo percutaneous permeation / In vitro drug release / Microemulsion hydrogels / Oil-in-water microemulsions / Polymers / Transdermal drug delivery
Source:
Microemulsions: Systems, Properties and Applications, 2016, 1-36
Publisher:
  • Nova Science Publishers, Inc.
Scopus: 2-s2.0-85017083353
[ Google Scholar ]
2
Handle
https://hdl.handle.net/21.15107/rcub_farfar_2702
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2702
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - CHAP
AU  - Đekić, Ljiljana
AU  - Martinović, Martina
AU  - Primorac, Marija
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2702
AB  - The current research in cutaneous and percutaneous drug delivery is focused on design of advanced carriers with enhanced applicability, stability, drug-loading capacity, and drug penetration/permeation ability. Microemulsion hydrogels (MHs) are carriers which attract the attention of a growing number of researchers who aimed to enhace dermal or transdermal delivery of drugs which are common therapeutics for different skin disorders or systemic deseases such as infections, androgenic alopecia, rheumatoid arthritis, osteoarthritis, and spondylitis, respectively. Microemulsion hydrogels is a heterogeneous group of the drug delivery systems which usually represent thermodynamically stable systems comprising dispersed oil phase within a continuous aqueous phase which is thickened with a suitable hydrophilic polymer. This chapter summarises a novel observations regarding physicochemical properties, physical and chemical stability, and drug delivery potential of this type of drug delivery systems, based on comprehensive review of the research results from the relevant scientific publications. Particularly, the chapter describes the rheological behaviour of microemulsion hydrogels and elucidates the role of the most commonly used synthetic and natural hydrophilic polymers (such as carbomers, hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), xanthan gum, poloxamers) as gelling agents. Furthermore, the recently established models of the complex structure of different microemulsion hydrogels, the in vitro drug release profiles, the ex vivo permeation profiles, and the in vivo drug delivery availability of different drug molecules from the investigated systems, are described. The skin compatibility and skin irritation potential aspect of the selected hydrogel-thickened microemulsion systems is commented. The most important findings of the selected studies on microemulsion hydrogels were presented in order to illustrate their potential for achievement of topical, regional or transdermal drug delivery, including sustained drug delivery, as well as to compare to that of conventional hydrogels, microemulsions, and creams.
PB  - Nova Science Publishers, Inc.
T2  - Microemulsions: Systems, Properties and Applications
T1  - Microemulsion hydrogels - properties and current applications in drug delivery
SP  - 1
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2702
ER  - 
@inbook{
author = "Đekić, Ljiljana and Martinović, Martina and Primorac, Marija",
year = "2016",
abstract = "The current research in cutaneous and percutaneous drug delivery is focused on design of advanced carriers with enhanced applicability, stability, drug-loading capacity, and drug penetration/permeation ability. Microemulsion hydrogels (MHs) are carriers which attract the attention of a growing number of researchers who aimed to enhace dermal or transdermal delivery of drugs which are common therapeutics for different skin disorders or systemic deseases such as infections, androgenic alopecia, rheumatoid arthritis, osteoarthritis, and spondylitis, respectively. Microemulsion hydrogels is a heterogeneous group of the drug delivery systems which usually represent thermodynamically stable systems comprising dispersed oil phase within a continuous aqueous phase which is thickened with a suitable hydrophilic polymer. This chapter summarises a novel observations regarding physicochemical properties, physical and chemical stability, and drug delivery potential of this type of drug delivery systems, based on comprehensive review of the research results from the relevant scientific publications. Particularly, the chapter describes the rheological behaviour of microemulsion hydrogels and elucidates the role of the most commonly used synthetic and natural hydrophilic polymers (such as carbomers, hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), xanthan gum, poloxamers) as gelling agents. Furthermore, the recently established models of the complex structure of different microemulsion hydrogels, the in vitro drug release profiles, the ex vivo permeation profiles, and the in vivo drug delivery availability of different drug molecules from the investigated systems, are described. The skin compatibility and skin irritation potential aspect of the selected hydrogel-thickened microemulsion systems is commented. The most important findings of the selected studies on microemulsion hydrogels were presented in order to illustrate their potential for achievement of topical, regional or transdermal drug delivery, including sustained drug delivery, as well as to compare to that of conventional hydrogels, microemulsions, and creams.",
publisher = "Nova Science Publishers, Inc.",
journal = "Microemulsions: Systems, Properties and Applications",
booktitle = "Microemulsion hydrogels - properties and current applications in drug delivery",
pages = "1-36",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2702"
}
Đekić, L., Martinović, M.,& Primorac, M.. (2016). Microemulsion hydrogels - properties and current applications in drug delivery. in Microemulsions: Systems, Properties and Applications
Nova Science Publishers, Inc.., 1-36.
https://hdl.handle.net/21.15107/rcub_farfar_2702
Đekić L, Martinović M, Primorac M. Microemulsion hydrogels - properties and current applications in drug delivery. in Microemulsions: Systems, Properties and Applications. 2016;:1-36.
https://hdl.handle.net/21.15107/rcub_farfar_2702 .
Đekić, Ljiljana, Martinović, Martina, Primorac, Marija, "Microemulsion hydrogels - properties and current applications in drug delivery" in Microemulsions: Systems, Properties and Applications (2016):1-36,
https://hdl.handle.net/21.15107/rcub_farfar_2702 .

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